Studies of ulcerative colitis

Engel, George L.

doi:10.1016/0002-9343(55)90377-6

Cited by 196 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A fam ily histo ry of infla mmato ry bowe l disea se in 22% of patien ts is co mpa ra ble wit h that of othe r studies . Sev eral stud ies ha ve sho wn co ncordance for UC in families of pat ients , but this wa s not e vident in o ur st ud y (29,30).…”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis in Children 10 Years Old or Younger

Gryboski

1993

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

SummaryThe onset and course of ulcerative colitis diagnosed in 38 children at or before 10 years of age were reviewed. The mean age at onset was 5.9 years. A family history of inflammatory bowel disease was present in 24% of patients, and 13% had a history of cow milk allergy in infancy. Initially, by radiologic or colonoscopic studies, 71% had total colonic disease, 13% had left‐sided colitis, and 6% had proctitis: extensive examination was not performed in 4 patients. Four patients (11%) presented with severe colitis. 14 (37%) with moderate colitis, and 20 (53%) with mild colitis. The most frequent symptoms were abdominal pain (94%), diarrhea (84%), and rectal bleeding (84%). Between 2 and 10 years after diagnosis, 89% of children had total colonic disease and 11% had left‐sided disease. All four patients with severe disease at onset responded to medical therapy with one having a colectomy 15 years later with pathology consistent with Crohn's disease. Of those with moderate disease, half had infrequent moderate recurrences and half had intermittent mild disease. One patient had colectomy at 21 years for intractable disease. Of the 20 with mild disease, 16 continued to have intermittent mild recurrences, I had chronic mild disease. 2 had moderate recurrent disease, and 1 has remained asymptomatic for 5 years. Psychiatric disturbances requiring therapy were identified in 5 (13%) children. Results are encouraging: after the first 2 years of illness, two thirds of the children have had subsequent mild colitis with infrequent relapses and three quarters consider their life to be of good quality.

show abstract

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis in Children 10 Years Old or Younger

Gryboski

1993

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…To illustrate, uncontrollability during stress (e.g., during "helplessness" test paradigms) was found to predispose animals to gastric ulceration [37], intestinal inflammation, intestinal epithelial permeability [38][39][40][41], altered composition of the microbiota [42], hyper-reactivity of the GI tract [43], and (chemically induced) colitis [44]. Similarly, in patients suffering from IBD, episodes of bleeding and relapse were shown to occur almost exclusively following a subjective experience of being "absolutely crushed", "helpless", "hopeless", "powerless", "shocked", and "endangered or enraged but powerless to do anything" [45]. Thus, to summarize, uncontrollable stressful experiences may severely increase IBD patients' inflammatory and functional symptom profiles and decrease their quality of life, most likely as a function of diminished efficacy experiences.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Psychotrauma and Emotional Stress Vulnerability on Physical and Mental Functioning of Patients with Inflammatory Bowel Disease

Nass,

Dibbets,

Markus

2023

IJERPH

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic health condition thought to be influenced by personal life experiences and emotional stress sensitivity (neuroticism). In the present study, we examined the impact of cumulative trauma experiences and trait neuroticism (as a measure for emotional stress vulnerability) on physical and mental functioning of n = 211 patients diagnosed with IBD (112 Crohn’s disease, 99 ulcerative colitis). All patients were assessed for self-reported trauma histories, emotional stress vulnerability, clinical disease activity, functional gastrointestinal (GI) symptoms, and quality of life. Results showed that patients with severe IBD activity have endured significantly more interpersonal trauma and victimization than those with quiescent IBD. Moreover, cumulative trauma was found to exert an indirect (neuroticism-mediated) effect on patients’ symptom complexity, with trauma and neuroticism conjointly explaining 16–21% of the variance in gastrointestinal and 35% of the variance in mental symptoms. Upon correction for condition (using a small group of available controls, n = 51), the predictive capacity of trauma and neuroticism increased further, with both predictors now explaining 31% of the somatic—and almost 50% of the mental symptom heterogeneity. In terms of trauma type, victimization (domestic violence and intimate abuse) proved the best predictor of cross-sample symptom variability and the only trauma profile with a consistent direct and indirect (neuroticism-mediated) effect on patients’ mental (QoL) and physical fitness. Results are consistent with the growing body of evidence linking experiential vulnerability factors (trauma and neuroticism) and associated feelings of personal ineffectiveness, helplessness, and uncontrollability to interindividual differences in (GI) disease activity and quality of life.

show abstract

“…M. Sperling (personal communication) and Engel (1955) report relapses of ulcerative colitis on the anniversaries of earlier episodes. M. Sperling (personal communication) and Engel (1955) report relapses of ulcerative colitis on the anniversaries of earlier episodes.…”

mentioning

confidence: 99%

The Anniversary Reaction: a Response to the Unconscious Sense of Time

Mintz¹

1971

J Am Psychoanal Assoc

View full text Add to dashboard Cite

Studies of ulcerative colitis

Cited by 196 publications

References 44 publications

Ulcerative Colitis in Children 10 Years Old or Younger

Ulcerative Colitis in Children 10 Years Old or Younger

The Impact of Psychotrauma and Emotional Stress Vulnerability on Physical and Mental Functioning of Patients with Inflammatory Bowel Disease

The Anniversary Reaction: a Response to the Unconscious Sense of Time

Contact Info

Product

Resources

About