Studies of tumour invasion in organ culture

Yarnell, Margaret M.; Ambrose, E. J.

doi:10.1016/0014-2964(69)90075-9

Cited by 12 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is considerable evidence that proteolytic enzymes are present in animal neoplasms (Ottoson and Sylven, 1960) and that collagenolytic enzymes occur in many human tumours (Taylor, Levy and Simpson, 1970;Dresden, Heilman and Schmidt, 1972;Yamanishi, Dabbous and Hashimoto, 1972). Also, trypsin has been shown to encourage the invasion of malignant cells into foetal tissues in in vitro systems (Yarnell and Ambrose, 1969).…”

mentioning

confidence: 99%

Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor

Latner¹,

Longstaff²,

Pradhan³

1973

Br J Cancer

View full text Add to dashboard Cite

Summary.-The inhibitory effect of the protease inhibitor aprotinin (Trasylol) on the invasion of mouse kidney explants by polyoma virus transformed BHK21 cells was investigated using a mixed cell/organ culture technique. The extent of invasion was monitored by following the changes in LDH isoenzyme pattern in the explants and by histological assessment. The kidney explants containing aprotinin were found to maintain a normal kidney LDH pattern and to suffer considerably less invasion than the explants not containing the drug. These results support the idea that proteolytic enzymes are associated with invasion and that inhibitors of protease activity could possibly be useful in the management of clinical cancer.

show abstract

mentioning

confidence: 99%

Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor

Latner¹,

Longstaff²,

Pradhan³

1973

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…On the other hand, the expression of sialic acids by fungal species which cause local infections with little tendency to spread argues against a role of sialic acids in fungal invasiveness. In contrast, a protection against tumor invasiveness has been reported after neuraminidase treatment [31]. A highly invasive tumor--malignant melanoma-has virtually all surface glycoproteins highly sialylated [17].…”

Section: ( Canavalia Ensif Ormis)mentioning

confidence: 94%

Identification of sialic acids on the cell surface of hyphae and conidia of the human pathogenFonsecaea pedrosoi

et al. 1986

View full text Add to dashboard Cite

Sialic acids were characterized on the cell surface of conidia and hyphae of Fonsecaea pedrosoi, one of the agents of chromoblastomycosis. Neuraminidase-treated conidia had a reduced negative electrophoretic mobility and, in comparison with untreated cells, bound fewer particles of colloidal iron hydroxide and of cationized ferritin. Sialie acid residues in conidia are linked to galactopyranosyl units as indicated by the increased reactivity of neuraminidase-treated cells with peanut agglutinin. N-acetylneuraminic acid was the only derivative found in the mycelium whereas conidia contained both N-glycolyl-and N-acetylneuraminic acids.

show abstract

“…Hence it is probable that tumour cells are able to release enzymes that can degrade the proteoglycan matrix as well as the collagen fibres of connective tissues, including those in basement membranes. Further evidence that leucocytes are not required for tumour cell invasiveness comes from observations that virus-transformed BHK 21 cells can invade chick embryo organs and kidney explants in culture (Yarnell and Ambrose, 1969;Latner, Longstaff, and Pradhan, 1973).…”

Section: Lysosomal Enzymes and Tumour Invasivenessmentioning

confidence: 99%

Lysosomes in cancer cells

Allison¹

1974

Journal of Clinical Pathology

View full text Add to dashboard Cite

Studies of tumour invasion in organ culture

Cited by 12 publications

References 14 publications

Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor

Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor

Identification of sialic acids on the cell surface of hyphae and conidia of the human pathogenFonsecaea pedrosoi

Lysosomes in cancer cells

Contact Info

Product

Resources

About