Studies of the Skin of the Fetus and the Child

Serri, F; Montagna, William; Mescon, Herbert

doi:10.1038/jid.1962.104

Cited by 44 publications

(14 citation statements)

References 14 publications

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“…Emergent hair shafts can be seen by 17 weeks on the brow and over the entire scalp at 18 weeks (5). The development of follicles spreads in a cephalocaudal direction (6).…”

Section: Embryologymentioning

confidence: 99%

Normal Hair Growth in Children

Barth

1987

Pediatric Dermatology

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Abnormalities in the hair growth of children are common reasons for referral to a dermatologist or pediatrician. There is wide variation in the normal sequence of development of hair form and pattern in childhood and adolescence. Very occasionally, abnormalities may be a component of complex metabolic disorders. Therefore it is important to recognize the normal growth of children's hair. Most diagnoses of hair disorders may be made on clinical examination and inspection of hair shafts and roots under a light microscope.

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“…Emergent hair shafts can be seen by 17 weeks on the brow and over the entire scalp at 18 weeks (5). The development of follicles spreads in a cephalocaudal direction (6).…”

Section: Embryologymentioning

confidence: 99%

Normal Hair Growth in Children

Barth

1987

Pediatric Dermatology

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“…Maximal increases in glycogen content were found on day 3 post-injury, at which time marginal epithelium exhibited 3 times normal and the distal halves of migrating epithelium exhibited 7 to 13 times normal levels. Glycogen is abundant in embryonic epidermis and disappears gradually as the skin develops in ontogenesis (Serri et al, 1962). Our results signify that regenerating epithelium may represent regression to a primitive embryonic germinal state.…”

Section: Resultsmentioning

confidence: 51%

“…Glycogen is abundant in fetal epidermis and present in low concentration in adult epidermis (Serri et al, 1962). It is well documented that glycogen content increases in adult epidermis following epithelial stripping with adhesive tape (Lobitz and Holyoke, 1954), x-ray (Adachi, 1961) and ultraviolet irradiation (Ohkawara et al, 1972), and in association with psoriasis (Halprin and Ohkawara, 1966).…”

Section: Introductionmentioning

confidence: 99%

Glycogen metabolism in epidermal wound healing

Hoopes

1974

Journal of Surgical Oncology

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Enzymatic cycling methods have been applied t o the quantitative measurement of glycogen content during wound healing and utilized for an estimation of the contribution of glycogen to metabolism in association with ischemia. Tissue glycogen accumulated in regenerating epithelium during the fnst 7 days of wound healing. Increasing gradients of glycogen concentration were demonstrated from the marginal epithelium to the distal portions of the migrating epithelium. Glycogen content was increased t o 13 times normal in the distal portion of migrating epithelium on day 3 post-injury. A study of ischemia revealed that the accumulated glycogen appeared to constitute an emergency ration for repairing epithelium and contributed considerably to energy production.

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“…The distribution of alkaline phosphatase in vitro is also similar to that at various stages of development in vivo, as described by Serri et al (1963). This is of particular interest as it is generally greatly increased when the balance between stroma and epithelium is disturbed, as in healing wounds (Fell & Danielli, 1943), in chemical carcinogenesis (Biesele & Biesele, 1944) and in human squamous carcinoma (Kawakatsu & Mori, 1963).…”

Section: Cysteine Desulphurasementioning

confidence: 61%

Enzyme histochemistry of developing human skin in tissue culture

PULLAR,

LIADSKY

1965

Journal of the Royal Microscopical Society

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SYNOPSISHuman foetal skin can develop in tissue culture using a synthetic chemically defined medium. The development produces squamous type epithelium which subsequently forms keratin. The assumption of squamous morphology is associated with the appearance of a reaction for acid phosphatase, non‐specific esterase and cysteine desulphurase. These enzymes show a distinct intensification in the zone between the squamous and keratin layers. The findings suggest that the process in this system closely parallels that in vivo.

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Studies of the Skin of the Fetus and the Child

Cited by 44 publications

References 14 publications

Normal Hair Growth in Children

Normal Hair Growth in Children

Glycogen metabolism in epidermal wound healing

Enzyme histochemistry of developing human skin in tissue culture

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