Studies of the role of the central nucleus of the amygdala in controlling cardiovascular functions

Baklavadzhyan, O. G.; Pogosyan, N. L.; Arshakyan, A V; Darbinyan, Armine; Khachatryan, Artak; Nikogosyan, T G

doi:10.1007/bf02463163

Cited by 20 publications

(14 citation statements)

References 9 publications

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“…The CeA M sends GABAergic projections to NTS and DMV (83, 84) that mediate autonomic (i.e., parasympathetic) responses to aversive stimuli (85) and contribute to chronic stress-induced hypertension (86). …”

Section: Cea As a Hub For Anxiety And Alcohol Circuitsmentioning

confidence: 99%

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

Gilpin

Herman²,

Roberto³

2015

Biological Psychiatry

382

314

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The central amygdala (CeA) plays a central role in physiological and behavioral responses to fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from cortical regions, is the major output region of the amygdala, is primarily GABAergic (inhibitory), and expresses high levels of pro- and anti-stress peptides. The CeA is also a constituent region of a conceptual macrostructure called the extended amygdala that is recruited during the transition to alcohol dependence. In this review, we discuss neurotransmission in the CeA as a potential integrative hub between anxiety disorders and Alcohol Use Disorder (AUD), which are commonly co-occurring in humans. Human imaging work and multi-disciplinary work in animals collectively suggest that CeA structure and function are altered in individuals with anxiety disorders and AUD, the end result of which may be disinhibition of downstream “effector” regions that regulate anxiety- and alcohol-related behaviors.

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Section: Cea As a Hub For Anxiety And Alcohol Circuitsmentioning

confidence: 99%

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

Gilpin

Herman²,

Roberto³

2015

Biological Psychiatry

382

314

View full text Add to dashboard Cite

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“…As with glucocorticoid release, increases in heart rate, blood pressure, and SCRs are often associated with stress-related stimuli, and several studies suggest that CeA activity is a key contributor to these sympathetic increases (84–88). Thus, in accordance with (C1) and (C2), one might expect vmPFC activity to be associated with an inhibition of these stress-related responses (i.e., increases in heart rate, blood pressure, and SCRs) via down-regulation of CeA output.…”

Section: Major Depression Post-traumatic Stress Disorder and Amentioning

confidence: 99%

Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders

2011

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In recent years, an increasing number of neuroimaging studies have sought to identify the brain anomalies associated with mood and anxiety disorders. The results of such studies could have significant implications for the development of novel treatments for these disorders. A challenge currently facing the field is to assimilate the large and growing corpus of imaging data to inform a systems-level model of the neural circuitry underlying the disorders. One prominent theoretical perspective highlights the top-down inhibition of amygdala by ventromedial prefrontal cortex (vmPFC) as a crucial neural mechanism that may be defective in certain mood and anxiety disorders, such as major depression and post-traumatic stress disorder. In this article we provide a critical review of animal and human data related to this model. In particular, we emphasize the considerable body of research that challenges the veracity (or at least completeness) of the predominant model. We propose a framework for constructing a more comprehensive model of vmPFC function, with the goal of fostering further progress in understanding the neuropathophysiological basis of mood and anxiety disorders.

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“…It was also reported that electrical or chemical lesions of the CeA in spontaneously hypertensive rats prevented the pressor responses (Galeno et al, 1982;Sharma & Gelsema, 1995;Saha, 2005). The lesions of the CeA also prevented the development of neurogenic hypertension in rats subjected to chronic stress (Baklavadzhyan et al, 2000). Therefore, stimulation of this region has been used to mimic physiological responses of the CeA in fear or stress (Iwata et al, 1987;Langevin et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

The role of NO in the posterior hypothalamus in amygdala‐generated pressor responses in conscious rats

Bayraktar

Yananlı

Terzioĝlu

et al. 2013

Auton Autocoid Pharmacol

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The nitrergic system modulates cardiovascular functions of the central nucleus of amygdala (CeA) and the posterior hypothalamus (PH) which are involved in the central regulation of the cardiovascular system. The aim of this study was to investigate the contribution of nitric oxide (NO) in the PH in eliciting cardiovascular responses produced through electrical stimulation (ES) of the CeA. Rats were implanted with a stimulation electrode and a parenchymal cannula system into the CeA and a parenchymal cannula or a microdialysis probe into the PH. The next day, the femoral artery was cannulated for haemodynamic measurement. The CeA was electrically stimulated to produce cardiovascular response. The nitric oxide synthetase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 400 nmol/100 nl) or artificial cerebrospinal fluid were injected into the PH or the CeA before the ES of the CeA. The dialysates were collected from the PH to determine the L-citrulline and the L-glutamic acid levels. L-NAME injection into the CeA but not to the PH suppressed the increases in the mean arterial pressure produced by the ES of the CeA significantly; however, heart rate was not affected by L-NAME injection into either the PH or the CeA. L-citrulline and L-glutamic acid levels in the PH were shown to be increased by the ES of the CeA. NO is involved between the PH and the CeA which has a considerable role in the central regulation of the cardiovascular system.

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Studies of the role of the central nucleus of the amygdala in controlling cardiovascular functions

Cited by 20 publications

References 9 publications

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders

The role of NO in the posterior hypothalamus in amygdala‐generated pressor responses in conscious rats

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