1997
DOI: 10.1038/sj.mp.4000207
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Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors

Abstract: Abnormalities in the dopaminergic reward pathways have frequently been implicated in substance abuse and addictive behaviors. Recent studies by Self and coworkers have suggested an important interaction between the dopamine D 1 and D 2 receptors in cocaine abuse. To test the hypothesis that the DRD1 gene might play a role in addictive behaviors we examined the alleles of the Dde I polymorphism in three independent groups of subjects with varying types of compulsive, addictive behaviors -Tourette syndrome proba… Show more

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Cited by 204 publications
(125 citation statements)
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References 18 publications
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“…1 Although others have reported similar associations, [6][7][8] in other cases our data have not been replicated and different genes have been associated with PG. 8,9 These results could be in agreement with the existence of different models for this polygenic disorder in such a way that different sets of genes are altered in different sets of pathological gamblers.…”
supporting
confidence: 79%
“…1 Although others have reported similar associations, [6][7][8] in other cases our data have not been replicated and different genes have been associated with PG. 8,9 These results could be in agreement with the existence of different models for this polygenic disorder in such a way that different sets of genes are altered in different sets of pathological gamblers.…”
supporting
confidence: 79%
“…A total of 28 studies published between 1994 and 2007, comprising k = 34 independent samples, were identifi ed by the search strategy, met the inclusion criteria, and contributed to the metaanalysis ( Bierut et al, 2000 ;Comings et al, 1996Comings et al, , 1997Connor et al, 2007 ;Costa-Mallen et al, 2000 ;David et al, 2007 ;Erblich, Lerman, Self, Diaz, & Bovbjerg, 2004Freire, Marques, Hutz, & Bau, 2006 ;Hamajima et al, 2002 ;Johnstone, Yudkin, Griffi ths, et al, 2004 ;Lee, 2003 ;Lerman et al, 1999Lerman et al, , 2003Morton et al, 2006 ;Noble et al, 1994 ;Preuss, Zill, Koller, Bondy, & Sokya, 2007 ;Qi, Tan, Xing, Miao, & Lin, 2002 ;Robinson et al, 2006 ;Sabol et al, 1999 ;Singleton et al, 1998 ;Spitz et al, 1998 ;Swan et al, 2005 ;Timberlake et al, 2007 ;Ton et al, 2007 ;Wu, Hudmon, Detry, Chamberlain, & Spitz, 2000 ;Yoshida et al, 2001 ). Data from the present study also were included in the meta-analysis.…”
Section: Description Of Studies In Meta-analysismentioning
confidence: 99%
“…When studies that recruited samples of predominantly East Asian ancestry were analyzed separately ( k = 5), we found no strong evidence of association in either the fi xed-effects ( OR = 0.89, p = .23) or the random-effects ( OR = 0.86, p = .49) model. Metaregression, excluding two studies ( Comings et al, 1997 ;Wu et al, 2000 ) comprising three samples in which data were not available, indicated a positive association between effect size and proportion of male participants (Z = 3.71, p < .001), suggesting increasing effect size with increasing proportion of male participants (<50% male: k = 7, OR = 0.93, 95% CI = 0.84 -1.03, Z = 1.38, p = .17; >50% male: k = 11, OR = 1.32, 95% CI = 1.17 -1.48, Z = 4.60, p < .001; Figure 3 ). Excluding the data from the present study did not alter these results substantially.…”
Section: Meta-analysismentioning
confidence: 99%
“…In another study of the DRD1 and DRD2 genes, the Comings' group used a questionnaire-based measure of DSM-IV ADHD symptoms, as we do in this study. 11 Thus, they treated ADHD symptoms as a continuous trait rather than as a diagnostic category. They found that ADHD symptoms correlated positively with the A1 allele of DRD2.…”
mentioning
confidence: 99%