Studies of the Irritating Action of Methylcellulose

Fleming, Thomas C.; Merrill, David L.; Girard, Louis

doi:10.1001/archopht.1959.00940090567011

Cited by 16 publications

(3 citation statements)

References 4 publications

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“…Two monomers of glucose combine to form cellobiase linked by beta-glycosidic bonds. Therefore, humans are believed to be unable to decompose and metabolize MC [26,27], In the present study, 1% MC did not alter the GAG profile of the TM, indicating that TM cells cannot metabolize MC.…”

Section: Discussionmentioning

confidence: 37%

Biochemical Effects of Viscoelastic Materials on the Glycosaminoglycans in the Organ-Cultured Rabbit Trabecular Meshwork

Tofukuji

1994

Ophthalmologica

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We studied the effects of viscoelastic materials on the glycosaminoglycan (GAG) profiles in the organ-cultured rabbit trabecular meshwork (TM). The cultured specimens were divided into 4 groups: (1) control group; (2) 1% sodium hyaluronate-(Na-HA)-treated group; (3) 3% chondroitin-6-sulfate (CDÓS)-treated group, and (4) 1% methylcellulose (MC)-treated group. They were cultured for 2 weeks and subjected to sequential enzymatic degradation. In the 1% Na-HA-treated group, the proportion of hyaluronic acid was significantly increased compared with the control group. In the 3% CD6S-treated group, the proportion of chondroitin sulfate was significantly increased compared with the control group. In the 1% MC-treated group, the GAG profile did not differ from the control profile.

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Section: Discussionmentioning

confidence: 37%

Biochemical Effects of Viscoelastic Materials on the Glycosaminoglycans in the Organ-Cultured Rabbit Trabecular Meshwork

Tofukuji

1994

Ophthalmologica

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“…Flemming also presented some conclusions regarding the experiment of MC irritation. Tissue culture studies on human conjunctival and corneal epithelium showed no evidence of inhibition of cellular growth or toxic effect when subjected to a 0.5% solution of MC (5). MC has been investigated as a tear substitute and as an ophthalmic vehicle due to its viscosity and slow drainage through the lacrimal passage.…”

Section: Discussionmentioning

confidence: 99%

Influences of Methylcellulose on Corneal Epithelial Wound Healing

Lin

Boehnke²

1999

Journal of Ocular Pharmacology and Therapeutics

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We performed a study to evaluate the influence of methylcellulose (MC) on the corneal epithelial wound healing. A precise epithelial wound 2.0 mm in diameter and 70 microm in depth was created by an excimer laser on the cornea of a pig's eyeball. After treatment, the eyeballs were cultured in the incubator and perfused with TC-199 medium into the vitreous cavity. Topical MC with eight different combinations of concentrations and viscosities for experimental groups and BSS for the control group were applied on the epithelial defects three times. Wounds were evaluated 24 hours later with fluorescein stain and recorded with a scoring system. All of the experimental groups except one showed a more statistically significant superior wound-healing rate than the control group. MC possesses the effect to accelerate corneal epithelial wound healing.

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“…2 Robert and co-workers3 injected 2% HPMC into rabbit anterior chambers and observed corneal oedema and anterior cham ber fibrin during the first week. Histopath- ologic studies of the eyes at 3, 6, 13 and 25 days were normal.…”

mentioning

confidence: 99%

Hydroxypropyl methylcellulose in extracapsular cataract surgery with intraocular lens implantation: Intraocular pressure and inflammatory response

Chumbley

Morgan

Musallam

1990

Eye

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SummaryWe studied prospectively the effects of 2% hydroxypropylmethylcellulose (HPMC), instilled in to the anterior chamber during extracapsular cataract extraction with posterior chamber intraocular lens implantation in 122 patients. Significant pres sure rise was noted at 12 and 24 hours post-operatively when HPMC was not removed at the end of surgery. This was prevented by washing HPMC from the anterior chamber at the end of surgery, or by using either acetazolamide or a combi nation of oxyphenbutazone and vitamin C without washing HPMC. There was no difference in intraocular inflammation between controls and the HPMC groups. The group receiving acetazolamide without washing HPMC had the most inflammation, while the group receiving combined oxyphenbutazone and vitamin C had the least, the differences between these two groups being sufficient.

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Studies of the Irritating Action of Methylcellulose

Cited by 16 publications

References 4 publications

Biochemical Effects of Viscoelastic Materials on the Glycosaminoglycans in the Organ-Cultured Rabbit Trabecular Meshwork

Biochemical Effects of Viscoelastic Materials on the Glycosaminoglycans in the Organ-Cultured Rabbit Trabecular Meshwork

Influences of Methylcellulose on Corneal Epithelial Wound Healing

Hydroxypropyl methylcellulose in extracapsular cataract surgery with intraocular lens implantation: Intraocular pressure and inflammatory response

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