Studies of the Epidemiology of Staphylococcal Infection

Gf, Thofrnton; Fekety, Robert; Le, Cluff

doi:10.1056/nejm196412242712602

Cited by 12 publications

(1 citation statement)

References 18 publications

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“…The over-all number of admissions, average duration of hospitalization, and use of antimicrobials were similar throughout the 5-month period of surveillance. This pattern of winter predominance may be similar to the recently reported seasonal variations in nosocomial staphylococcal wound infections (15). An expanded year-long surveillance program is in progress to define the seasonal variations in intestinal colonization and its relationship to extraintestinal infection more precisely.…”

Section: Resultssupporting

confidence: 82%

Studies on the Epidemiology of Escherichia coli Infections. V. Factors Influencing Acquisition of Specific Serologic Groups*

Winterbauer¹,

Turck²,

Petersdorf³

1967

J. Clin. Invest.

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Summary. Stool carrier rates of Escherichia coli serogroups 4, 6, and 75 were determined on admission and discharge for 190 patients. Persons who were in the hospital 3 weeks or longer had an intestinal carrier rate of 46% compared to a rate of 28% in individuals who had no recent hospital contact. Treatment with broad spectrum antibiotics increased the susceptibility for acquisition of certain specific serologic groups. This was apparently not related to replacement of sensitive E. coli by drug-resistant forms. Studies were made to determine the environmental source for colonization of hospitalized patients and the risk of urinary infection in stool carriers of these strains. A survey of inanimate objects of medical and urological wards demonstrated infrequent isolation of 04, 06, and 075, indicating that extraintestinal foci were an unlikely source for hospital-acquired E. coli. Hemagglutination titers with determination of group-specific 0 antibody failed to demonstrate any deficiency in hospitalized patients who became colonized with certain coliforms. Similarly, no significant deficit in group-specific serum antibody was found in patients who were community carriers of E. coli 04, 06, or 075. Despite a high rate of acquisition of E. coli serogroups 4, 6, and 75 in the stools of hospitalized patients, only those patients undergoing urinary tract manipulation developed bacteriuria.

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Section: Resultssupporting

confidence: 82%