Studies of the elderly in Boston. I. The effects of iron fortification on moderately anemic people

Gershoff, Stanley N.; Brusis, O A; Nino, Hipolito V.; Huber, Agnes

doi:10.1093/ajcn/30.2.226

Cited by 31 publications

(3 citation statements)

References 4 publications

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“…In agreement to the previous studies of Ahmad et al and Gershoff et al ( 10 , 28 ), our study observed that serum iron levels were significantly improved in all the groups of anemic women when fed with iron fortificants and prebiotics, compared to the control group. Furthermore, maximum values of both RBC count and MCV levels were reported in group G 4 fed with 963 mg/kg GOS and 30 ppm FeSO 4 as compared to other treatment groups.…”

Section: Discussionsupporting

confidence: 93%

Effect of inulin, galacto oligosaccharides and iron fortification on iron deficiency anemia among women of reproductive age; a randomized controlled trial

et al. 2022

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Iron supplementation and fortification are the well-known approaches to treat iron deficiency anemia (IDA) in women of reproductive age. The objective of the current randomized controlled trial (RCT) was to evaluate the cumulative effects of prebiotics and iron fortification among women of reproductive age. For this purpose, a total of 75 iron deficient women of childbearing age were recruited and randomly divided into 5 groups (4 treatment groups and 1 control group). Four different types of fortified wheat flour were prepared using two iron fortificants (NaFeEDTA and FeSO4) and two prebiotics [inulin and galacto oligosaccharides (GOS)], while control group was treated with iron fortified flour without any prebiotics. Blood samples were collected from overnight fasted women on monthly basis up to 90 days. Hematological indices such as Hemoglobin (Hb), Hematocrit, Red Blood Cell (RBC) Count and Mean Corpuscular Volume (MCV), as well as iron biomarkers including serum iron, ferritin, transferrin, and Total Iron Binding Capacity (TIBC) were evaluated for analyses. The results showed a considerable positive improvement in all iron biomarkers as well as hematological indices among the treatment groups (P-value < 0.05), as compared to the control group. A maximum Hb (11.86 ± 0.24 mg/dL) and hematocrit value (35.06 ± 1.32%), was reported in group G3 which was treated with fortified wheat flour at a dose of 963 mg/kg GOS + 15 ppm FeSO4. On the other hand, highest mean values for RBC Count (4.73 ± 0.41 mil/mm3), MCV (81.41 ± 3.21 fL), serum iron (75.62 ± 2.79 μg/dL), serum transferrin (16.82 ± 0.30 mg/dL), and TIBC (403.68 ± 7.27 μg/dL) were observed in G4 group receiving the fortified wheat flour at a dose of 963 mg/kg GOS + 30 ppm FeSO4 level. The study concluded that prebiotic fortification along with iron salts helps to enhance iron absorption among iron deficiency anemic women of reproductive age.

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Section: Discussionsupporting

confidence: 93%

Effect of inulin, galacto oligosaccharides and iron fortification on iron deficiency anemia among women of reproductive age; a randomized controlled trial

et al. 2022

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“…Even in the healthy, the hemoglobin (Hb) concentration tends to decrease with age with no apparent cause [1][2][3]. The causation of anemia in the elderly has been investigated but still re mains unknown [4][5][6][7][8][9].…”

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confidence: 99%

Serum Erythropoietin Levels in the Elderly

1991

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We evaluated the relationship between erythropoietin (EPO) and hemoglobin (Hb) concentrations in 156 normal subjects ranging from 60 to 98 years old. EPO was determined by a radioimmunoassay. The serum EPO concentration in subjects with Hb concentrations greater than 12.0 g/dl (26.9 ± 15.2 mU/ml), was significantly higher than that in younger controls (15.8 ± 5.0 mU/ml, p < 0.001). No sex difference in serum EPO level was detected. In addition, there was an inverse semilogarithmic relationship between EPO and Hb concentrations in subjects with Hb concentrations less than 12.0 g/dl (r = ––0.559, p < 0.001). EPO concentrations in the elderly were lower than those in young subjects with iron deficiency anemia with the same Hb level. Thus, in the elderly, a high EPO concentration may be preventing a decrease in the Hb concentration. However, a decreased EPO response to low Hb concentrations may be a contributing factor in anemia in the elderly.

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“…At the end of study, hemoglobin and serum iron levels of both the groups were compared and it was seen that the group which received fortified grain products had increased levels of hemoglobin as well as serum iron. The researchers concluded that iron fortification of grain products helps anemic elderly regain their normal hemoglobin as well as serum iron levels (Gershoff et al., 1977). Our study results are exactly in accordance with this particular study as we have also concluded that iron fortification tends to improve serum iron levels in anemic subjects.…”

Section: Discussionmentioning

confidence: 99%

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

Ahmad

Farooq²,

Anees

et al. 2022

Food Science & Nutrition

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Micronutrient deficiencies affect approximately 2 billion people worldwide and iron deficiency anemia is one of them. The instant research was an attempt to determine the efficacy of co‐administration of two iron fortificants (NaFeEDTA and FeSO4) and inulin (a prebiotic) on serum iron, ferritin, transferrin, and total iron‐binding capacity in iron‐deficient female Sprague Dawley rats. For this research, rats were divided into ten groups, (two control and eight treatment groups). Treatment groups were made iron deficient by feeding them with triapine, an iron binder for two weeks. All treatment groups were fed with inulin at two different dosage levels along with iron fortificants. The study results showed that serum ferritin and serum iron levels significantly improved from initiation to termination of study. Also, mean values of total iron‐binding capacity and serum transferrin showed a steady decline over a period of three months indicating that iron stores were being improved. It was concluded that co‐administration of inulin and iron fortificants helped improve iron deficiency biomarkers in female Sprague Dawley rats.

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Studies of the elderly in Boston. I. The effects of iron fortification on moderately anemic people

Cited by 31 publications

References 4 publications

Effect of inulin, galacto oligosaccharides and iron fortification on iron deficiency anemia among women of reproductive age; a randomized controlled trial

Effect of inulin, galacto oligosaccharides and iron fortification on iron deficiency anemia among women of reproductive age; a randomized controlled trial

Serum Erythropoietin Levels in the Elderly

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

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