Abstract:In 1929, Palmer, Carson, and Sloan (1) reported that treatment of exophthalmic goiter with Lugol's solution reduced or abolished the associated creatinuria. More recently Richardson and Shorr (2, 3) and Thorn (4) have shown that hyperthyroid individuals excrete a larger proportion of a given dose of creatine than do comparable normal individuals, and that this "reduced tolerance" is partially or totally reversible by effective therapy. The development by one of us of a practical method for the determination of… Show more
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