1981
DOI: 10.1042/bj1980247
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Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown

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Cited by 31 publications
(13 citation statements)
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“…When these studies were initiated it appeared that the metabolism of polyphosphoinositides was subject to few very rapid perturbations by hormones or neurotransmitters (for review, see ). However, it has since become apparent that this was an incorrect view; several stimuli provoke very rapid breakdown and/or turnover of Ptdlns(4,5)P2, and maybe also PtdIns4P, in a variety of cells (Abdel-Latif et Kirk et al, 1981b;Michell et al, 1981;Soukup & Schanberg, 1982;Billah & Lapetina, 1982;Weiss et al, 1982;Kirk, 1982;Berridge, 1982;Putney, 1982;Berridge et al, 1983;Putney et al, 1983). The effective ligands are those that both mobilize Ca2+ in the cytosol of stimulated cells and cause the disappearance of some fraction of the cell's Ptdlns (previously assumed to indicate its breakdown).…”
Section: Discussionmentioning
confidence: 99%
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“…When these studies were initiated it appeared that the metabolism of polyphosphoinositides was subject to few very rapid perturbations by hormones or neurotransmitters (for review, see ). However, it has since become apparent that this was an incorrect view; several stimuli provoke very rapid breakdown and/or turnover of Ptdlns(4,5)P2, and maybe also PtdIns4P, in a variety of cells (Abdel-Latif et Kirk et al, 1981b;Michell et al, 1981;Soukup & Schanberg, 1982;Billah & Lapetina, 1982;Weiss et al, 1982;Kirk, 1982;Berridge, 1982;Putney, 1982;Berridge et al, 1983;Putney et al, 1983). The effective ligands are those that both mobilize Ca2+ in the cytosol of stimulated cells and cause the disappearance of some fraction of the cell's Ptdlns (previously assumed to indicate its breakdown).…”
Section: Discussionmentioning
confidence: 99%
“…An obvious and mechanistically economical possibility is that the activation of a single metabolic reaction leads to the decreases in the concentrations of all three inositol lipids. As realised first by , the two most likely candidates for this primary step are breakdown of Ptdlns catalysed by the PtdIns-specific phospholipase C of the cytosol (Michell, 1975;Irvine et al 1982;Shukla, 1982) or breakdown of polyphosphoinositides catalysed by a plasma-membrane phosphodiesterase similar to that of the erythrocyte (Abdel-Latif et al, 1977Hawthorne & Pickard, 1979;Kirk et al, 1981b;Michell et al, 1981;Downes & Michell, 1982a,b). Final confirmation that a phosphodiesterase is indeed implicated was recently obtained by Berridge etal.…”
Section: The Relationship Between Stimulation Of Polyphosphoinositidementioning
confidence: 99%
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“…Our current findings, how¬ ever, are inconsistent with this hypothesis, and force an adjustment of our model of the confluent pathways involved in phosphoinositide-associated signal trans¬ duction. There is now an appreciable consensus that the phosphodiesteratic hydrolysis of phosphoinositides is among the earliest of intracellular events to be promoted by receptor activation, with consequent resynthesis as an attendant, latent process (for reviews see Micheli & Kirk, 1981;Gershengorn, 1985;Hokin, 1985). Dopaminergic attenuation of phospholipid radiolabelling must, therefore, occur through some mechanism other than an inhibitor of phosphoinositide catabolism.…”
Section: Discussionmentioning
confidence: 99%
“…These compounds have been shown to be metabolically very active in brain and are thought to be intimately involved with synaptic processes as well as other membrane-receptor-mediated responses (see reviews bj7 Michell, 1975;Hawthorne and Pickard, 1979;13erridge, 1981). The actual role of phosphoinositicle metabolism in these processes remains unclear, and some aspects are controversial (Michell and Kirk, 1981;Hawthorne, 1982;Michell, 1982). Therle is little doubt, however, of the widespread, and perhaps universal, involvement of phosphoinositide metabolism in stimulus-response coupling.…”
Section: Discussionmentioning
confidence: 99%