Studies of perennial ragweed immunotherapy

Irons, John S.; Pruzansky, Jacob J.; Patterson, Roy; Zeiss, C. Raymond

doi:10.1016/0091-6749(77)90149-x

Cited by 32 publications

(1 citation statement)

References 31 publications

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“…Because of the impracticability of readily isolating the various al lergenic components from such mixtures, antibody responses to common environmental allergens have been determined for the most part either in terms of gross effects measured against the whole extract, such as is routinely employed in many RAST [19] and ELI ZA [11] assay systems, or somewhat less commonly, so-called major component allergens have been em ployed as representative markers, as exemplified by radioimmunoassay systems using highly purified and radioiodinated ragweed antigen E [7,17] or rye group I [13,16] materials.…”

Section: Introductionmentioning

confidence: 99%

Antibody Response Profiles to Components of Rye Grass Pollen Extract in Various Strains of Mice

Moran

Standring

Henderson

1982

Int Arch Allergy Immunol

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Using a combination of immunoprecipitation and polyacrylamide gel electrophoresis techniques, patterns of antibody responses to a number of components in rye pollen extract have been studied in hyperimmune mouse sera. Common laboratory strains of mice were investigated, including AKR, C₃H/H_e, SwR, Ist, Asn, Balb/c, C₅₇BL₁₀, DBA₂ and BD1: F1 hybrids. All strains responded vigorously to the immunisation protocol used (rye pollen extract/alum followed by a booster dose in aqueous media) when tested with non-discriminating assay procedures such as haemagglutination or passive cutaneous anaphylaxis directed against the whole rye pollen extract. However, markedly variable antibody responses were observed between strains and between murine and human sera when considered in relation to individual rye extract components. Particularly noteworthy was the relatively poor response of all mice to the low molecular weight rye antigen component (11,000 daltons). This material was readily detected by human sera derived from pollenosis patients. Notable also was the fact that no single rye component was detected by all mice sera. These results illustrate the complex serological response induced by heterogeneous antigen mixtures, such as grass pollen extracts.

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Section: Introductionmentioning

confidence: 99%

Antibody Response Profiles to Components of Rye Grass Pollen Extract in Various Strains of Mice

Moran

Standring

Henderson

1982

Int Arch Allergy Immunol

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A Study of Optimum Dose Immunotherapy in Pharmacological Treatment Failures

Fadal¹,

Nalebuff²

1980

Archives of Otolaryngology - Head and Neck Surgery

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Aggressive Coseasonal Immunotherapy in Mountain Cedar Pollen Allergy

Lee¹,

Kniker²

1982

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\ Ninety adults with "mountain cedar" pollen allergy were started on coseasonal immunotherapy regimens in December 1979. At season's end, there were 20 whose starting antigen dose was based on serial dilution end point titration (SDET), 1:2,500 or 1:12,500 weight by volume (w/v); 28 in a "traditional" group started at 1:62,500 w/v; and 28 who had been double-blind placebo control subjects. Injections twice weekly were pushed aggressively toward maintenance. The SDET group received 11 times more antigen than the traditional group; both showed a trend for fewer symptoms than the placebo group. As compared with the other groups, SDET subjects had substantially blunted total and specific IgE responses in season, lower specific IgE level at season's end and less shift of skin end point toward higher dilutions. The findings demonstrate that substantial immunologic effects are possible in the first months of aggressive coseasonal immunotherapy.

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Studies of perennial ragweed immunotherapy

Cited by 32 publications

References 31 publications

Antibody Response Profiles to Components of Rye Grass Pollen Extract in Various Strains of Mice

Antibody Response Profiles to Components of Rye Grass Pollen Extract in Various Strains of Mice

A Study of Optimum Dose Immunotherapy in Pharmacological Treatment Failures

Aggressive Coseasonal Immunotherapy in Mountain Cedar Pollen Allergy

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