“…It is of interest, however, that patients who responded to prednisolone therapy were those with higher titers of circulating parietal cell antibody. High titers of parietal cell antibody, persisting for many years after the diagnosis of pernicious anemia has been established (11,18), may reflect a continuing stimulation of antibody production by parietal cell antigen released from degenerating mucosal cells. The three patients who did not respond to prednisolone therapy had low titers of parietal cell antibody and exhibited extensive intestinal metaplasia in their gastric mucosal biopsies.…”