Studies of Pantothenic Acid Metabolism

Lubin, Robert I.; Daum, Kate; Bean, William B.; Bradbury, James T.; Gunning, Ruth; Routh, Joseph I.; Tung, I. Chu

doi:10.1093/ajcn/4.4.420

Cited by 15 publications

(8 citation statements)

References 5 publications

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“…What Williams (41) has emphasized as biochemical individuality and Medawar (42) as the uniqueness of the individual, we see in the personal quirks and inconsistent biochemical patterns which bedevil the framers of human nutritional experiments and make exasperating the necessarily unsatisfactory solution of the problem of controls. We be absorbed too rapidly, analagous in part to the dumping syndrome (1,2,4,5). After omitting the hydrolysis employed previously in preparing the formula this phenomenon did not appear.…”

Section: Discussionmentioning

confidence: 99%

“…They might have come from the individual differences in response to a deficiency of pantothenic acid or variations in requirement. These abnormalities include the faulty acetylation of para-aminobenzoic acid (1, 2) and the development of arrhythmias, cardiovascular instability and electrocardiographic abnormalities (4,5). The depression of urinary 17- …”

Section: Discussionmentioning

confidence: 99%

“…At least two avenues of investigation lay before us: to prepare and feed a diet devoid of pantothenic acid, or to give analogs of the vitamin and test possible antivitamin effects. Experiences in devising a deficient diet and testing several antagonists have been described (1)(2)(3)(4)(5). Clinical and laboratory abnormalities appeared in healthy young men given an artificial diet, partly synthetic and partly of purified ingredients, the whole virtually devoid of pantothenic acid.…”

mentioning

confidence: 99%

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Pantothenic Acid Deficiency in Man1

Hodges¹,

Ohlson²,

Bean³

1958

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Pantothenic Acid Deficiency in Man1

Hodges¹,

Ohlson²,

Bean³

1958

J. Clin. Invest.

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“…Complete collections were made of urine and feces for nitrogen determination to compare with aliquots of the daily diet. Determinations were made each (3,4 we had found impairment of gastric secretion in patients who were deficient in pantothenic acid b)ut this was not found in later studies (3)(4)(5)(6).…”

Section: Methodsmentioning

confidence: 87%

“…This study and subsequent ones demonstrated that young men fed a purified, partly synthetic diet deficient in pantothenic acid, became ill after about 12 weeks (1,2). By adding omega-methyl pantothenic acid to the deficient diet, we were able to induce illness in about four weeks (3)(4)(5). The details of this illness and of the unpredictable results stemming from unforeseen peculiarities of the test program have been described (4)(5)(6).…”

mentioning

confidence: 82%

Human Pantothenic Acid Deficiency Produced by Omega-Methyl Pantothenic Acid *

Hodges¹,

Bean²,

Ohlson³

et al. 1959

J. Clin. Invest.

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Counselors, Nutrition, and Mental Health

Pearson¹,

Long²

1982

The Personnel and Guidance Journal

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Awareness of the relationships between dietary intake and mental health may prompt counselors to pursue new avenues for helping clients. This article discusses current nutritional trends and the ways our bodies convert foods into chemicals that (1980), who notes that nutritional components play a role in a number of common client complaints, urges counselors to realize the possibility that a client's emotions may be aggravated or intensified by inappropriate eating habits. For some time, scientists, such as Spies (1958), have been investigating the dietary intake of psychiatric patients and recommending dietary interventions for the treatment of emotional disorders. Some experts in the nutrition field now contend that our phenomenal increases in mental illness, crime, substance abuse, learning disabilities, and inability to cope with daily stress could stem, in part, from an improper diet. Cheraskin and Ringsdorf (1975) in fact believe that food nutrients are the key to emotional health. They hypothesize that poor nutrition may contribute to schizophrenia, alcoholism, drug abuse, psychosis, depression, nervousness, irritability, learning disorders, and disturbed interpersonal relationships.The topic is a controversial one, connected with the longstanding debate over the duality of mental and physical functioning. Many might ask why we should be concerned about proper nutrition when Americans are among the healthiest, best-fed people in the world? Robinson (1976) answers that "although most Americans have enjoyed the most abundant diet in the world . . . this very affluence is creating imbalances that contribute to many chronic diseases" (p.126). Ballentine (1979) notes that the American diet has undergone remarkable. changes in the last 70 years. Consumption of grains, for example, has fallen by 50%, accounting significantly in the 80% drop in fiber intake. Meat now replaces grains as a main source of protein. Beef consumption has increased by nearly 75% while the consumption of poultry has tripled. Sugar use is up 31%. Fats, oils and sugars constitute 60% to 70% of the average MARCH 1982 diet. Alcohol accounts for 10% to 20% of the total caloric intake for adults (Gerler, 1979). Fresh fruit and vegetable consumption is down.But changed eating habits are not the only problem. Some contend that technological advances in the food industry often destroy the nutritional value of foods (Ballentine, 1979). It is well-known that canned and frozen products lose many of their vitamins and minerals through processing. Our foods now contain artificial flavorings, colorings, and chemical additives, some of which are potentially dangerous to health. Ballentine's conclusion is that only 50% of the U.S. population has an adequate diet.Facts such as these may hold significant implications for counseling. If nutrition is a determining factor in mental illness, it is possible that counseling and psychotherapy could be aided by dietary interventions,. If dietary deficiencies lead to impaired metabolism that influences thought and m...

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Studies of Pantothenic Acid Metabolism

Cited by 15 publications

References 5 publications

Pantothenic Acid Deficiency in Man1

Pantothenic Acid Deficiency in Man1

Human Pantothenic Acid Deficiency Produced by Omega-Methyl Pantothenic Acid *

Counselors, Nutrition, and Mental Health

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