Studies of New Layer Formation on the Surface of Zinc Doped Hydroxyapatite/Chitosan Composite Coatings in Biological Medium

Abstract

Usually, before being used in biomedical applications, a biomaterials’ bioactivity is tested by in vitro methods that simulate similar conditions to those found in the human body. In this work, we report on the synthesis of zinc-doped hydroxyapatite–chitosan (ZnHApC) composite coatings by the vacuum deposition method. The surface microstructure and the chemical and molecular modification of the coatings before and after soaking in DMEM (Dulbecco’s Modified Eagle’s Medium) were studied. For this objective, techniques such as attenuated total reflection (ATR), Fourier transform infrared (FTIR) spectroscopy, metallographic microscopy (MM), and scanning electron microscopy (SEM) were applied used. Also, water contact angle measurements and swelling studies were made on ZnHApC composite coatings before and after soaking in a biological medium. The coatings’ adherence to the substrate was also studied. The results of antifungal studies on ZnHApC composite coatings against the Candida albicans microbial strain reveal their good antifungal activity. The biocompatibility of the composite coatings was tested using a primary osteoblast cell line. Our results suggest that zinc-doped hydroxyapatite–chitosan samples could be used as a bioimplant material due to their enhanced bioactivity and biocompatibility.

Biocomposite Coatings Doped with Magnesium and Zinc Ions in Chitosan Matrix for Antimicrobial Applications

“…Law [53], obtaining a θ value under 90 • highlights the presence of a hydrophilic surface. Therefore, our results align well with the results reported in the literature, and they may indicate that the composite coatings based on MgZnHAp_Ch can be promising candidates for biomedical use due to their hydrophilic surface features [5,41,54,55].…”

“…For the water contact angle measurements, a contact angle goniometer (DSA30 Kruess GmbH, Germany) was used. The procedure was conducted under ambient conditions, in accordance with the conditions reported in our previous work [ 41 ]. In this paper, the values of θ (°) ± SD are reported.…”

Ag2O-Containing Biocidal Interpolyelectrolyte Complexes on Glass Surfaces—Adhesive Properties of the Coatings

“…In order to support the assumption above, the contact angles of water on the coatings were studied. The presence of a significant share of inorganic particles of Ag 2 O should cause the distinguishable change of the water contact angle on the surface of the polymer films [ 54 ]. The freshly cleaned glass had a contact angle of 30°, and formation of the coating from PDADMAC resulted in slight hydrophilization of the surface (the contact angle was found to be 20°).…”

Development of Dextran Coated Zinc Oxide Nanoparticles with Antimicrobial Properties

“…More than that, zinc ions play an important role in various physiological processes within the human body. Beyond its wellknown functions in immune system modulation and wound healing, zinc has recently gained attention for its remarkable antimicrobial properties [14][15][16][17]. On the other hand, dextran is also a natural polysaccharide composed of glucose molecules whose biological properties made it of exceptional use in biomedical applications.…”