Studies of I131-Albumin Catabolism and Distribution in Normal Young Male Adults*

Beeken, Warren L.; Volwiler, Wade; Goldsworthy, Patrick D.; Garby, Lars; Reynolds, William E.; Stogsdill, Rose; Stemler, Richard S.

doi:10.1172/jci104594

Cited by 133 publications

(58 citation statements)

References 53 publications

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“…The biologic behavior of albumin-125I is quite similar to that of albumin-1311, as these data agree with published figures for halflife, total exchangeable albumin, and turnover rate (20)(21)(22). Based en of total daily catabolism.…”

Section: Calculationssupporting

confidence: 87%

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

Kerr¹,

Bois²,

Holt³

1967

J. Clin. Invest.

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Abstract. A method for the simultaneous measurement of gastrointestinal protein loss and total albumin turnover entailing the use of a combination of 125iodine-and 51chromium-labeled albumin is described. Albumin turnover was calculated by the measurement of albumin-125I plasma decay and cumulative urinary excretion, and the results obtained agreed closely with previous studies utilizing albumin-'31I. Gastrointestinal catabolism was calculated from the rate of fecal excretion of 51Cr and the specific activity of plasma albumin-51Cr, and these data were related to the calculated albumin turnover results. During the period of 6-14 days after administration, the ratio of specific activties of albumin-125I and -51Cr in plasma and in extravascular spaces or gastric and biliary secretions remained almost identical. Fecal excretion of 51Cr was also quite stable at this time. In six normal subjects gastrointestinal catabolism accounted for less than 10% of total albumin catabolism. Excessive gastrointestinal protein losses did not contribute to the low serum albumin in three patients with cirrhosis or in two adults with the nephrotic syndrome. Multiple mechanisms leading to hypoalbuminemia were demonstrated in other subjects with a variety of gastrointestinal disorders.

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Section: Calculationssupporting

confidence: 87%

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

Kerr¹,

Bois²,

Holt³

1967

J. Clin. Invest.

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“…Notably, ;80% of 2.4G2 Fab was cleared within 2 hours of administration, whereas 2.4G2 scFv-MSA stayed higher than the Fab throughout all time points studied ( Figure 2C). Previous findings show that the half-life of albumin in humans is ;13 to 18 days, 27,28 whereas that of mice is ;1 day. 29 The findings in this in vivo pharmacokinetics study are therefore consistent with previous reports and support the establishment that the half-life of albumin in mice is shorter than humans.…”

Section: Resultsmentioning

confidence: 95%

“…Previous studies have conclusively established that the in vivo longevity of albumin is directly proportional to the size of the animal, with mice having the shortest half-life. 27,28,[48][49][50] This shorter half-life of albumin in mice prevented us from establishing a therapeutic ITP mouse model, as such a model requires the treatment to typically stay in circulation for 2 days to enable detection of the therapeutic effects. 51 Thus, independent models involving larger animals could help investigate its efficacy in active ITP or in other FcgR-implicated diseases.…”

mentioning

confidence: 99%

Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

Menard

Prechl

et al. 2016

Blood

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“…Lastly, Cavalieri, Steinberg, and Searle, by use of constant infusion techniques, have estimated that the liver distribution space of T3 in normal males is 2.75 liters (18). Assuming a total cellular distribution of space of T3 of 33 liters (= total T3 distribution space of 40 liters [5] -albumin space of 7 liters [19]) the hepatic space of T3 would constitute only 8.3% of the total cellular T3 space. The same authors have estimated that the hepatic distribution space of T4 is 3.8 liters (20).…”

Section: Discussionmentioning

confidence: 99%

Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3′-L-triiodothyronine and L-thyroxine

Oppenheimer¹,

Schwartz²,

Shapiro³

et al. 1970

J. Clin. Invest.

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A B S T R A C T Administration of phenobarbital, which acts exclusively on cellular sites, results in an augmentation of the liver/plasma concentration ratio of L-thyroxine (T4) in rats but no change in the liver/plasma concentration ratio of L-triiodothyronine (T3). Whereas phenobarbital stimulates the fecal clearance rate both of T3 and T4, it increases the deiodinative clearance rate of T4 only. These findings suggest basic differences in the cellular metabolism of T3 and T4. Further evidence pointing to cellular differences was obtained from a comparison of the distribution and metabolism of these hormones with appropriate corrections for the effect of differential plasma binding. The percentage of total exchangeable cellular T4 within the liver (28.5) is significantly greater than the corresponding percentage of exchangeable cellular T3 within this organ (12.3). Extrahepatic tissues bind T3 twice as firmly as T4. The cellular metabolic clearance rate (= free hormone clearance rate) of T3 exceeds that of T4 by a factor 1.8 in the rat. The corresponding ratio in man, 2.4, was determined by noncompartmental analysis of turnover studies in four individuals after the simultaneous injection of T4-'I and T3-2"I. The greater cellular metabolic clearance rate of T3 both in rat and man may be related to the higher specific hormonal potency of this iodothyronine.

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Studies of I131-Albumin Catabolism and Distribution in Normal Young Male Adults*

Cited by 133 publications

References 53 publications

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3′-L-triiodothyronine and L-thyroxine

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