Studies of formation of W/O nano-emulsions

Porras, M.; Solans, Conxita; González, Carlos; Martínez, A.; Guinart, A.; Gutiérrez, José Marı́a

doi:10.1016/j.colsurfa.2004.08.060

Cited by 178 publications

(94 citation statements)

References 8 publications

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“…Up to now various oil/surfactant mixtures are known to form nanoemulsions spontaneously upon dilution with water, e.g. Span and Tween surfactants mixed with decane, 25,26 potassium oleate/C 12 E 10 and hexadecane, 27 or oleylammonium chloride/oleylamine/C 12 E 10 and hexadecane. 28 However, up to date there is no systematic knowledge regarding the molecular composition of the oil/surfactant combinations required to successfully obtain a nanoemulsion.…”

Section: -14mentioning

confidence: 99%

Formation and structure of slightly anionically charged nanoemulsions obtained by the phase inversion concentration (PIC) method

et al. 2011

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While nanoemulsions (10-200 nm) are not thermodynamically stable systems they can exhibit quite long term stability. In this paper oil/surfactant mixtures, containing diethylhexyl carbonate/ phenoxyethanol/parabens as oil and polyglyceryl-4 laurate/dilauryl citrate as surfactant, form nanoemulsions simply by dilution with water, i.e. by means of the phase inversion concentration (PIC) method. In order to study this highly interesting phenomenon an investigation at constant oil-tosurfactant (O/S) ratio was done by means of viscosity, conductivity, and UV/Vis-transmittance measurements. This phase study as a function of the dilution by water shows that at an intermediate water content a two-phase system of bicontinuous structure is formed, which exhibits a very pronounced viscosity and conductivity maximum shortly before the homogeneous nanoemulsion phase is reached. In the same region SANS shows a high degree of ordering of this bicontinuous structure. SANS and cryo-TEM investigations of the nanoemulsion regime show an increasing average size with dilution and, more interestingly, the presence of two populations with different average particle sizes around 10-15 nm and 25-40 nm. The relative proportion of each population depends on the amount of added water, leading to an average growth of the particle size with increasing dilution.

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Section: -14mentioning

confidence: 99%

Formation and structure of slightly anionically charged nanoemulsions obtained by the phase inversion concentration (PIC) method

et al. 2011

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“…A sealing with commercial epoxy was done near the sidewall to prevent a leakage between the syringe and the membrane. After a preparation of a sample with pre-emulsions by the reported procedure 45 , we obtained a sample with polydispersive water emulsions (mean diameter: 261.9 nm) by mixing a small amount of water in hexadecane with an aid of surfactant (1:1 ratio of Span-20 and Tween-80). A liquid flow (1 ml min À 1 ) through an array of multilevel apertures (800 nm/20 mm/500 mm) can provide jetting of emulsion flow via an individual aperture (Fig.…”

Section: Demonstration Of Emulsion Reorganization Via Nano-aperturesmentioning

confidence: 99%

Replication of flexible polymer membranes with geometry-controllable nano-apertures via a hierarchical mould-based dewetting

et al. 2014

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Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymeric membrane with nano-apertures by exploiting high-wettability difference and geometrical reinforcement via multiscale, multilevel architecture. In the method, polymeric membranes with various pore sizes (50-800 nm) and shapes (dots, lines) are fabricated by a hierarchical mould-based dewetting of ultravioletcurable resins. In particular, the nano-pores are monolithically integrated on a two-level hierarchical supporting layer, allowing for the rapid (o5 min) and robust formation of multiscale and multilevel nano-apertures over large areas (2 Â 2 cm 2 ).

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“…Of the low-energy emulsifying methods, PIC method has been the most commonly used. In the PIC process, the stability and droplet size are greatly influenced by oil/surfactant ratio, hydrophile-lipophile balance (HLB) of surfactants, and fractions of components in the system (29,30). In general, optimum formulation was selected on the basis of pseudo-ternary phase diagrams.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery

Zhang

Shang

Gao³

et al. 2014

AAPS PharmSciTech

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Abstract. Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good protection and oral delivery system, an optimal nanoemulsion for pterostilbene was developed by using low-energy emulsification method. Systematic pseudo-ternary phase diagrams have been studied in optimization of nanoemulsion formulations. The prepared pterostilbene nanoemulsion was characterized by transmission electron microscope, Fourier transform Raman spectrum, and laser droplet size analyzer. Nanoemulsion droplets are circular with smooth margin, and the mean size is 55.8± 10.5 nm. The results illustrated that the nanoemulsion as oral delivery system dramatically improved the stability and solubility of pterostilbene, and in vitro release of pterostilbene was significantly improved (96.5% in pH 3.6 buffer; 13.2% in pH 7.4 buffer) in comparison to the pterostilbene suspension (lower than 21.4% in pH 3.6 buffer; 2.6% in pH 7.4 buffer).

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Studies of formation of W/O nano-emulsions

Cited by 178 publications

References 8 publications

Formation and structure of slightly anionically charged nanoemulsions obtained by the phase inversion concentration (PIC) method

Formation and structure of slightly anionically charged nanoemulsions obtained by the phase inversion concentration (PIC) method

Replication of flexible polymer membranes with geometry-controllable nano-apertures via a hierarchical mould-based dewetting

Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery

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