Studies of fluoride metabolism in man

Spencer, Herta; Osis, Dace; Lender, Menahem

doi:10.1016/0048-9697(81)90103-0

Cited by 18 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, the association of magnesium and fluoride makes a powerful bronchodilator that acts at a micromolar dose range compared to NaF 0.5 M or MgSO4 (15%) alone. In the present study, inhaled doses of MgSO4, NaF and MgF2 were very low and far from the toxic doses of magnesium and fluoride (Spencer et al, 1981;Whitford, 1996;Akiniwa, 1997). It is difficult to assess the dose of MgF2 needed for the treatment of asthma as this study seems to be the first to demonstrate its bronchodilating effect in vivo.…”

Section: Figmentioning

confidence: 99%

Inhaled magnesium fluoride reverse bronchospasma

Gandia

Rouatbi

Latiri

et al. 2010

J. Smooth Muscle Res.

View full text Add to dashboard Cite

Asthma is a global health problem. Asthma attacks are becoming more severe and more resistant to usual treatment by β2 agonists nebulisation. The search for a new product that could reduce the morbidity of asthmatic disease seems necessary. The objective of this study was to compare the effectiveness of inhaled magnesium fluoride (MgF2) with that of magnesium sulphate (MgSO4) 15% alone and sodium fluoride (NaF) 0.5 M alone in rats precontracted by methacholine (MeCh). Fifty six adult male Wistar rats of medium weight 259 ± 15 g were divided randomly into five groups. They inhaled respectively: MeCh, MgF2 + NaCl 0.9%, MgF2 + acetic acid, MgSO4 15% single and NaF (0.5 M) single. Airway resistances were measured after each dose of MeCh by pneumomultitest equipment. Results indicated that (1) MgF2 + NaCl 0.9%, MgF2 + acetic acid and MgSO4 reversed significantly the methacholine-induced bronchial constriction in rats and had a bronchodilating effect at the moment of its administration (2) MgF2 + acetic acid led to a greater decrease (P<0.05) of bronchial resistances when compared to that obtained from MgF2 + NaCl 0.9%, NaF exclusively and MgSO4 alone (3) inhaled NaF alone led to a significant bronchorelaxing effect (P<0.05) that starts at the sixth dose of MeCh (17 mg/L). As a matter of fact, MgF2 dissolved in acetic acid and delivered in aerosol form reduces significantly bronchial spasm. In conclusion, MgF2 can be used as a bronchodilator for diseases with bronchospasma such as asthma and chronic obstructive pulmonary disease (COPD).

show abstract

Section: Figmentioning

confidence: 99%