Studies of Drugs Given Before Anaesthesia Xvii: The Natural and Semi-Synthetic Opiates

Loan, W.B.; Morrison, J. D.; Dundee, John W.; Clarke, R.S.J.; Hamilton, Robert C.; Brown, Stuart S.

doi:10.1093/bja/41.1.57

Search citation statements

Order By: Relevance

Paper Sections

Select...

Morphine Versus Diamorphine1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1977

2001

Publication Types

Select...

Article5

Book1

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 11 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given intravenously diamorphine acts more quickly than morphine, causes less vomiting and more sedation (27). This is advantageous for the pain of, for example, acute myocardial infarction, but not for chronic cancer pain.…”

Section: Morphine Versus Diamorphinementioning

confidence: 99%

Therapeutic Progress—review Xxiii Morphine Analgesia in Terminal Care

S¹

1986

J Clin Pharm Ther

View full text Add to dashboard Cite

show abstract

Section: Morphine Versus Diamorphinementioning

confidence: 99%

Therapeutic Progress—review Xxiii Morphine Analgesia in Terminal Care

S¹

1986

J Clin Pharm Ther

View full text Add to dashboard Cite

show abstract

Choice of strong analgesic in terminal cancer: Diamorphine or morphine?

Twycross

1977

Pain

108

View full text Add to dashboard Cite

A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients entered the trial and, of these, 146 crossed from diamorphine to morphine, or vice versa, after about two weeks using an oral potency ratio of 1.5/1 determined in a pilot trial. Additional medication and survival were closely similar in both treatment groups. In the female crossover patients, no difference was noted in relation either to pain or the other symptoms evaluated. On the other hand, male crossover patients experienced more pain, and were more depressed, while receiving diamorphine. In these, the potency ratio of diamorphine to morphine appeared to be less than 1.5/1. If this is allowed for, then the difference in mood is probably not significant. Compared with male patients, fewer females required a dose of 10 mg or more, but more were prescribed an anxiolytic. The ability to do without a 2 a.m. dose appeared to be related more to the size of the dose than to gender or treatment. It is concluded that, provided allowance is made for the difference in potency, morphine is a satisfactory substitute for orally administered diamorphine. However, when injections are necessary, the greater solubility of its hydrochloride gives diamorphine an important practical advantage over morphine, especially when large doses are required.

show abstract

Heroin for Cancer: A Great Non-Issue of Our Day

1984

The Lancet

View full text Add to dashboard Cite

Studies of Drugs Given Before Anaesthesia Xvii: The Natural and Semi-Synthetic Opiates

Cited by 11 publications

References 11 publications

Therapeutic Progress—review Xxiii Morphine Analgesia in Terminal Care

Therapeutic Progress—review Xxiii Morphine Analgesia in Terminal Care

Choice of strong analgesic in terminal cancer: Diamorphine or morphine?

Heroin for Cancer: A Great Non-Issue of Our Day

Contact Info

Product

Resources

About