Studies of Drugs Given Before Anaesthesia Xxi: Droperidol

Morrison, J.D.; Clarke, R.S.J.; Dundee, John W.

doi:10.1093/bja/42.8.730

Cited by 47 publications

(13 citation statements)

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“…Fentanyl is a potent analgesic with a short duration of action (20-30 min) in the dose used. However, unpleasant sideeffects of this combination have been reported repeatedly (2,3,4,5).…”

mentioning

confidence: 99%

Midazolam versus Fentanyl/Droperidol and Placebo as Intramuscular Premedicant

Wijhe

Voogt-Frenkel

Stijnen

1985

Acta Anaesthesiol Scand

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Midazolam, a new short-acting benzodiazepine with promising premedicant effects, was investigated in a double-blind, randomized clinical trial in 203 patients versus fentanyl/droperidol and placebo. Subjective effects, side-effects, amnesia and overall satisfaction were recorded. Midazolam caused the greatest decrease in anxiety level, and while causing more confusion and somnolence than placebo, caused less confusion and somnolence than fentanyl/droperidol. Half the patients who received midazolam reported anterograde amnesia. No serious side-effects were reported. Patient satisfaction was greater in the midazolam group than in the other groups.

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“…Fentanyl is a potent analgesic with a short duration of action (20-30 min) in the dose used. However, unpleasant sideeffects of this combination have been reported repeatedly (2,3,4,5).…”

mentioning

confidence: 99%

Midazolam versus Fentanyl/Droperidol and Placebo as Intramuscular Premedicant

Wijhe

Voogt-Frenkel

Stijnen

1985

Acta Anaesthesiol Scand

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“…Among others, EDMONDS-SEAL & PRYS-ROBERTS (1 970), ELLIS &WILSON ( 1972), andMORRISON et al (1970) have noted that in a considerable number of patients DHB has as a side-effect increased pre-and postoperative anxiety and tremor. However, this seems to apply only when the dose exceeds 10 mg.…”

Section: Discussionmentioning

confidence: 99%

The Postanesthetic Antiemetic Effect of Premedication with Dehydrobenzperidol Before Ether Anesthesia

Alsner

Brandt

Sørensen

1976

Acta Anaesthesiol Scand

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A study was performed to evaluate the antiemetic effects after ether anesthesia when dehydrobenzperidol (DHB) and pentobarbital were used for premedication and to compare these effects with halthane anesthesia when pentobarbital was used as premedication. Eighty-four patients undergoing minor surgical operations were randomly divided into three groups. The patients received ether and ether DHB 0.2 mg/kg or pentobarbital 2 mg/kg for premedication, or halothane and pentobarbital 2 mg/kg for premedication. The complaints of nausea and vomiting were recorded 24 h after anesthesia. We found that DHB compared to pentobarbital had a greater antiemetic effect after ether anesthesia, but the difference was not significant (P greater than 0.05). However, if only persistent nausea and vomiting were considered, the difference was significant (P less than 0.05). The incidence of nausea/vomiting after ether anesthesia with DHB as premedication was a little higher compared to halothane anesthesia with pentobarbital as premedication, but the difference was not significant (P greater than 0.05). However, if only persistent nausea/vomiting was considered, the incidence of complaints was equal in the two groups. It is concluded that when used for premedication to ether anesthesia DHB seems to lead to less postanesthetic nausea/vomiting than pentobarbital. Further DHB seems able to reduce the incidence of nausea/vomiting after ether anesthesia roughly to the level of that seen after pentobarbital premedication for halothane anesthesia.

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“…Droperidol is a butyrophenone similar to haloperidol which was initially used as an anesthetic premedication [1,2], Further experience showed it to be an effective postoperative antiemetic [3,4] and more recently it has been used for chemotherapyinduced nausea and vomiting. It has been suggested that it is superior to more conventional antiemetics in cis-platinum-induced emesis [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Droperidol as an Antiemetic in Cis-Platinum-Induced Nausea and Vomiting

Roberts¹,

Wisniewski²,

Cavanagh³

et al. 1985

Oncology

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23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an antiemetic regimen. Both the rate and duration of emesis were significantly lower when droperidol was used as the antiemetic regimen. There were no major side effects with either regimen. Droperidol seems to be superior to the combination of promethazine and chlorpromazine rectal suppositories in alleviating cis-platinum-induced nausea and vomiting.

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Studies of Drugs Given Before Anaesthesia Xxi: Droperidol

Cited by 47 publications

References 0 publications

Midazolam versus Fentanyl/Droperidol and Placebo as Intramuscular Premedicant

Midazolam versus Fentanyl/Droperidol and Placebo as Intramuscular Premedicant

The Postanesthetic Antiemetic Effect of Premedication with Dehydrobenzperidol Before Ether Anesthesia

Droperidol as an Antiemetic in Cis-Platinum-Induced Nausea and Vomiting

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