Studies into prekallikrein activation pave the way for new avenues of antithrombotic research

Li, Xian; Wood, Jeremy P.

doi:10.1111/jth.14435

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Encapsulated jujube powders containing WPI depicted the highest total phenolic content. Whey proteins preserve the encapsulants against oxidation because they have suitable emulsifying characteristics (Li & Wood, 2019).…”

Section: Resultsmentioning

confidence: 99%

The influence of sodium alginate and sodium alginate/ WPI as coating material on microcapsules of Jujube extract produced by spray dryer

Farahani

Mousavi

Ardebili

et al. 2022

Food Processing Preservation

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The aim of the research was to study the impact of various carrier types (sodium alginate and blend of sodium alginate with WPI) on the physicochemical, structural, and thermal characteristics of Jujube extract powder fabricated by spray drying. TPC and antioxidant activity, solubility, moisture, EE, powder yield, DSC, particle size, and morphology of powders were surveyed. The use of WPI resulted in powders with less moisture (10%), lower solubility (98.04%), and better powder yield (22.50%). WPI‐produced powders showed the best retention of polyphenolic compounds (2949.2 mg/L) and the highest activity of the encapsulation efficiency (70.93%), and moreover, they had a higher Tg (68.50°C), indicating powders that were more stable during storage. All samples showed a large number of spherical particles along with a number of indented particles, and these indentations were more common in protein capsules. In terms of particle diameter, the particles produced with alginate were smaller (6.51 μm). It can be stated that the particles containing proteins can have more effective and efficient outcomes. Novelty impact statement Both sodium alginate and sodium alginate/WPI powders were loaded with jujube extract (JE) by spray dryer. The encapsulation efficiency of jujube extract in sodium alginate/WPI powders was more. Incorporation of WPI to sodium alginate increased yield, moisture, solubility, and TPC and preserved jujube extract effectively.

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Section: Resultsmentioning

confidence: 99%

The influence of sodium alginate and sodium alginate/ WPI as coating material on microcapsules of Jujube extract produced by spray dryer

Farahani

Mousavi

Ardebili

et al. 2022

Food Processing Preservation

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“…The absence of overt severe clinical disturbances has led to a gradual decrement of clinical research on PK deficiency (Figure S1 in supporting information), although plasma kallikrein inhibition is emerging as an appealing therapy to modulate coagulation 8 and control bradykinin release. 5,6 Novel data concerning the genetic background and diagnostic criteria of PK deficiency are lacking.…”

Section: Introductionmentioning

confidence: 99%

Severe plasma prekallikrein deficiency: Clinical characteristics, novel KLKB1 mutations, and estimated prevalence

Sollfrank

Trinchero

Adenaeuer

et al. 2020

Journal of Thrombosis and Haemostasis

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Background: Severe plasma prekallikrein (PK) deficiency is an autosomal-recessive defect characterized by isolated activated partial thromboplastin time prolongation. To date, no comprehensive methodologically firm analysis has investigated the diagnostic, clinical, and genetic characteristics of PK deficiency, and its prevalence remains unknown.Patients/Methods: We described new families with PK deficiency, retrieved clinical and laboratory information of cases systematically searched in the (gray) literature, and collected blood of these cases for complementary analyses. The Genome Aggregation Database (gnomAD) and the population-based Gutenberg Health Study served to study the prevalence of mutations and relevant genetic variants. Results:We assembled a cohort of 111 cases from 89 families and performed new genetic analyses in eight families (three unpublished). We identified new KLKB1 mutations, excluded the pathogenicity of some of the previously described ones, and estimated a prevalence of severe PK deficiency of 1/155 668 overall and 1/4725 among Africans. One individual reported with PK deficiency had, in fact, congenital kininogen deficiency associated with decreased PK activity. One quarter of individuals had factor XII clotting activity below the reference range. Four major bleeding events were described in 96 individuals, of which 3 were provoked, for a prevalence of 4% and an annualized rate of 0.1%. The prevalence of cardiovascular events was 15% (6% <40 years; 21% 40-65 years; 33% >65 years) for an annualized rate of 0.4%. Conclusions:We characterized the genetic background of severe PK deficiency, critically appraised mutations, and provided prevalence estimates. Our data onThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | 1599BARCO et Al.

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“…( 2022a , 2022b , 2022c ) research shows that when the alginate matrix is used in the entire capsule structure, the amount of phenol extraction from capsules is less (2081.2 to 2949.2 mg gallic acid/L). Li and Wood ( 2019 ) acknowledged that the presence of whey protein can protect the compounds of the capsules from oxidation since it has the effects of creating an emulsion and the IFPG‐Al/WPI treatment showed the highest amount of phenolic compounds in the present work.…”

Section: Resultsmentioning

confidence: 62%

Performance of spray‐dried Ziziphus jujuba extract using insoluble fraction of Persian gum–sodium alginate and whey protein: Microstructural and physicochemical attributes of micro‐ and nano‐capsules

Khoshdouni Farahani,

Ebrahimzadeh Mousavi,

Seyedain Ardebili

et al. 2024

Food Science & Nutrition

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The study focused on the impact of the insoluble fraction of Persian gum–sodium alginate and a blend of the insoluble fraction of Persian gum–sodium alginate (IFPG‐Al) with whey protein isolate (WPI) on sprayed Ziziphus jujuba extract (JE) powder. The addition of whey protein led to powders with higher moisture (10%), higher solubility (99.19%), and lower powder yield (27.82%). The powders fabricated with WPI depicted the best protection of polyphenolic compounds (3933.4 mg/L) and the highest encapsulation efficiency activity (74.84%). Additionally, they had a higher Tg (62.63°C), which indicates more stability of the powders during shelf life. The sphericity of the majority of the particles was noticeable in powders, but multi‐sided concavities were visible in the protein‐containing particles. Based on the particle size's results, IFPG‐Al/WPI capsules fabricated relatively smaller particles (2.54 μm). It can be acknowledged that the presence of protein in particles can bring fruitful results by preserving valuable bioactive compounds.

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Studies into prekallikrein activation pave the way for new avenues of antithrombotic research

Cited by 4 publications

References 17 publications

The influence of sodium alginate and sodium alginate/ WPI as coating material on microcapsules of Jujube extract produced by spray dryer

The influence of sodium alginate and sodium alginate/ WPI as coating material on microcapsules of Jujube extract produced by spray dryer

Severe plasma prekallikrein deficiency: Clinical characteristics, novel KLKB1 mutations, and estimated prevalence

Performance of spray‐dried Ziziphus jujuba extract using insoluble fraction of Persian gum–sodium alginate and whey protein: Microstructural and physicochemical attributes of micro‐ and nano‐capsules

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