Studies in the Subgroups of the Blood Group A

Juel, Erik

doi:10.1111/j.1699-0463.1959.tb00336.x

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Molecular Genetics1

Other Fucosyltransferase Genes1

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1972

2013

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Cited by 4 publications

(2 citation statements)

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“…In Caucasian populations, le 202,314 and le 59,1067 are the two most frequent Lewis -negative alleles [174,180,181] , whereas le 59,508 is the most frequent in black Africans and in Eastern Asia (including le 59,508,980 in Africans) [87,174,177,181,182] (Table 2.8 ).…”

Section: Molecular Geneticsmentioning

confidence: 99%

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ABO, H, and Lewis Systems

Daniels

2013

Human Blood Groups

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Section: Molecular Geneticsmentioning

confidence: 99%

“…By agglutination of A 1 cells at room temperature, anti -A 1 was found in the serum of 1 -2% of A 2 and 22 -26% of A 2 B individuals [200,201] . More sensitive techniques revealed anti -A 1 in higher proportions of A 2 and A 2 B donors [202,203] .…”

Section: Other Fucosyltransferase Genesmentioning

confidence: 99%

ABO, H, and Lewis Systems

Daniels

2013

Human Blood Groups

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ABO, Hh, and Lewis Systems

2002

Human Blood Groups

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Studies with Ferritin‐Labelled Dolichos biflorus Lectin on the Numbers and Distribution of A Sites on A₁ and A₂ Erythrocytes, and on the Nature of its Specificity and Enhancement by Enzymes

Williams

Voak

1972

Br J Haematol

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Summary. The conjugation of Dolichos biflorus extract with ferritin produced an electron dense anti‐A reagent that was used to study the number and distribution of A sites on A1 and A2 red cells; there were five times as many ferritin‐labelled lectin molecules on A1 as on A2 cells (about 800,000: 150,000). The arrangement of sites on both A1 and A2 cells was diffuse but not random, as pattern analysis of the ferritin molecules revealed a contagious distribution of the sensitized A sites. It is suggested that the anti‐A1 saline test activity shown by the Dolichos reagent is due to the inefficiency of the small lectin molecules to bring about agglutination of the A2 cells. A2 cells have fewer sites and consequently a larger mean distance between their A sites than have A1 cells. Thus the probability of ‘bridging’ between the A sites of adjacent cells is reduced. Enzyme treatment increased lectin uptake and the A2 and B cells both bound over 8 million molecules per cell. The A2 cells gave agglutination reactions like untreated A1 cells but the B cells were not agglutinated. In areas of agglutination between the cells lectin molecules probably occurred mainly as a monolayer; however, in the other areas they occurred in multiple layers and only the first layer was in contact with cell membrane sites.

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Studies in the Subgroups of the Blood Group A

Cited by 4 publications

References 5 publications

ABO, H, and Lewis Systems

ABO, H, and Lewis Systems

ABO, Hh, and Lewis Systems

Studies with Ferritin‐Labelled Dolichos biflorus Lectin on the Numbers and Distribution of A Sites on A₁ and A₂ Erythrocytes, and on the Nature of its Specificity and Enhancement by Enzymes

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Studies in the Subgroups of the Blood Group A

Cited by 4 publications

References 5 publications

ABO, H, and Lewis Systems

ABO, H, and Lewis Systems

ABO, Hh, and Lewis Systems

Studies with Ferritin‐Labelled Dolichos biflorus Lectin on the Numbers and Distribution of A Sites on A1 and A2 Erythrocytes, and on the Nature of its Specificity and Enhancement by Enzymes

Contact Info

Product

Resources

About

Studies with Ferritin‐Labelled Dolichos biflorus Lectin on the Numbers and Distribution of A Sites on A₁ and A₂ Erythrocytes, and on the Nature of its Specificity and Enhancement by Enzymes