Studies in the quinone field XLVI. Synthesis of thioethers and sulfones in the 5-hydroxyindole series

Antimetastatic effects of arbidol, a new antiviral drug

“…Synthesis of various interferons and some other cytokines induced by them cannot eliminate the primary tumor but does have a marked impact on the level of metastases [6,7]. This lends urgency to the search for new substances characterized by interferon-inducing properties and their trials as antimetastatic agents.During synthetic investigations in the series of 2-alkyl(aryl)-thiomethyl-5-oxyindole derivatives we found that ethyl ether hydrochloride of 5-hydroxy-4-dimethylarninomethyl-1,2-phenylthiomethyl indole-3-carbonic acid, tentatively named fercaptolin, shows antiviral activity [4].Further search for new antiviral drugs revealed that one of the fercaptolm analogs, differing from it in the presence of bromine in position 6 (Fig. 1) The purpose of the present research was to study the antitumor and anti_metastatic effects of the new antiviral drug arbidol, possessing interferon-inducing properties, in models of induced and spontaneous metastasiNng of Lewis' pulmonary carcinoma.…”

“…Moreover, it stimulates interferon production by the organism [2]. After wide-scale clinical trials arbidol was authorized for medical use as an agent for the prevention and treatment of influenza [4]. The purpose of the present research was to study the antitumor and anti_metastatic effects of the new antiviral drug arbidol, possessing interferon-inducing properties, in models of induced and spontaneous metastasiNng of Lewis' pulmonary carcinoma.…”