Studies in the Pyrazole Series. III. Substituted Guanidines^1,2

Water‐Soluble Derivatives of Octanuclear Iron–Oxido–Pyrazolato Complexes – an Experimental and Computational Study

“…The four ligands, HL 1 – HL 4 , used for the synthesis of 1 – 4 , were synthesized by optimized literature procedures [18] and were characterized by 1 H- and 13 C-NMR. The organosoluble iron complexes 1 and 2 were prepared in one-pot reactions in CH 2 Cl 2 , while 3 and 4 in EtOH.…”

“…[18] 4-Chloroethyl pyrazole (HL 1 ) and 4-chloropropyl pyrazole (HL 2 ) were synthesized by chlorination of 4-HOCH 2 CH 2 -pzH and 4-HOCH 2 CH 2 CH 2 -pzH using thionyl chloride, followed by extraction in hot EtOH and crushing-out by diethylether. The chloroalkyl pyrazoles were further extracted into CH 2 Cl 2 to separate them from the starting hydroxyalkyl pyrazoles excess and finally dried under vacuum.…”

Synthesis of 1,1′-ferrocene bis(carboxypyrazole) compounds and displacement of the pyrazole ligands

“…However, no molybdenum containing compounds were isolated; nor were any pyrazoles isolated or observed in NMR spectra. It has been reported previously that transacylation reactions of N-acyl pyrazoles occur readily [19][20][21].…”

Micellization Behavior of Long-Chain Substituted Alkylguanidinium Surfactants

“…Several methods have been reported in the literature for the synthesis of guanidinium salts [ 20 ], including desulfurization-addition sequences, the addition of amines to electrophiles such as carbodiimides, cyanamides or chloramidinium salts [ 21 , 22 ], and the utilization of guanylation reagents [ 23 ]. The synthesis route employed here made use of 1 H -Pyrazol-1-carboxamidine hydrochloride as guanylating reagent [ 24 ]. This method allowed a nearly quantitative transformation of the starting material to the desired product under mild reaction conditions and afforded guanidinium salts in high purities and high yields [ 25 ].…”