Studies in the Physiology of Blood Vessels in Man. Iii. Some Effects of Raising and Lowering the Arm Upon the Pulse Volume and Blood Volume of the Human Finger Tip in Health and in Certain Diseases of the Blood Vessels 1

Turner, Roy H.; Burch, George E.; Sodeman, William A.

doi:10.1172/jci100905

Cited by 16 publications

(2 citation statements)

References 3 publications

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“…Preferably, the patient's finger should be in a position below heart level to maximize the blood fractional volume, 34 with the patient's forearm resting passively to minimize shear rate fluctuations on the blood flow that could affect its optical properties. 88 Moreover, since this measurement might need to be repeated a number of times during the treatment, it would be advisable to select a specific measurement site (e.g., at the center of the tactile elevations) for consistency.…”

Section: Resultsmentioning

confidence: 99%

“…In the second set, we repeat the simulations for the hypopigmented areas, more specifically the palmar fingertips of the LP and DP specimens. In these simulations, we took into account the particular characteristics of these cutaneous sites, namely the increased epidermal thickness, 31 the reduced presence of melanin proteins (more than fivefold lower than in nonpalmoplantar epidermis 32 ), and the increased blood fractional volume 33 (especially when the fingertip is in a position below heart level 34 ). Both sets of in silico experiments were performed with respect to UV, visible, and NIR regions of the light spectrum where skin spectral responses to variations in Hb concentration have a higher probability to be detected, more specifically, in the 250 to 850 nm range.…”

Section: Experimental Sets and Specimen Characterization Datamentioning

confidence: 99%

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Assessing the sensitivity of human skin hyperspectral responses to increasing anemia severity levels

2015

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Abstract. Anemia is a prevalent medical condition that seriously affects millions of people all over the world. In many regions, not only its initial detection but also its monitoring are hindered by limited access to laboratory facilities. This situation has motivated the development of a wide range of optical devices and procedures to assist physicians in these tasks. Although noticeable progress has been achieved in this area, the search for reliable, low-cost, and risk-free solutions still continues, and the strengthening of the knowledge base about this disorder and its effects is essential for the success of these initiatives. We contribute to these efforts by closely examining the sensitivity of human skin hyperspectral responses (within and outside the visible region of the light spectrum) to reduced hemoglobin concentrations associated with increasing anemia severity levels. This investigation, which involves skin specimens with distinct biophysical and morphological characteristics, is supported by controlled in silico experiments performed using a predictive light transport model and measured data reported in the biomedical literature. We also propose a noninvasive procedure to be employed in the monitoring of this condition at the point-of-care.

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Section: Resultsmentioning

confidence: 99%