STUDIES IN THE METABOLISM OF SODIUM r-LACTATE. III. RESPONSE OF HUMAN SUBJECTS WITH LIVER DAMAGE, DISTURBED WATER AND MINERAL BALANCE, AND RENAL INSUFFICIENCY TO THE INTRAVENOUS INJECTION OF SODIUM r-LACTATE

Hartmann, Alexis F.; Senn, Milton J. E.

doi:10.1172/jci100416

Cited by 39 publications

(13 citation statements)

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“…This is almost certainly due to the slow infusion rate with the peritoneal dialysis. Case reports of metabolic acidosis in neonates, potentiated by D(-)-lactate, and of delayed metabolism of lactate among patients with hepatitis raise the question of the advisability of using lactate-con taining dialysis solutions during these clinical episodes [16,17],…”

Section: Discussionmentioning

confidence: 99%

Stereospecific Lactate Absorption during Peritoneal Dialysis

Rubin

Adair

Johnson

et al. 1982

Nephron

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Patients undergoing peritoneal dialysis were studied to determine if peritoneal absorption was selective. Dialysis was performed using dialysate exchange schedules similar to those for intermittent peritoneal dialysis and continuous ambulatory peritoneal dialysis. The clearance rate from the peritoneal cavity during hourly dialysate exchanges was 6.2 ml/min for D (-)-lactate and 8.7 ml/min for L( + )-lactate (p < 0.01). L( + )-Lactate disappeared more rapidly from the dialysate during the long-cycle exchanges. Our results suggest that clearance of lactate from the peritoneal cavity is relatively stereospecific and raises the question of selective absorption for other organic anions.

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Section: Discussionmentioning

confidence: 99%

Stereospecific Lactate Absorption during Peritoneal Dialysis

Rubin

Adair

Johnson

et al. 1982

Nephron

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“…En 1932, el pediatra Alexis Hartmann modificó la solución de Ringer añadiéndole lactato de sodio, con el fin de evitar el desarrollo de acidosis en lactantes deshidratados por diarrea, dando lugar al suero que usamos en la actualidad 31 .…”

Section: Ringer Sidney (1835-1910)unclassified

Origen de epónimos comúnmente empleados en la Unidad de Cuidados Intensivos

F.¹,

S.²,

B.³

2018

Rev. chil. pediatr.

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Palabras clave:Cuidados Intensivos; biografía; epónimos; etimología; historia de la medicina ResumenLos epónimos reflejan la historia de la medicina, las enfermedades y los médicos en su época. Su uso es controversial, presentando partidarios y detractores. No obstante, el empleo de epónimos persiste en el lenguaje médico contemporáneo en las Unidades de Cuidados Intensivos e incluyen a algunos de frecuente uso como: Foley, Seldinger, Down, Macintosh, Magill, Ringer, Yankauer, Doppler y French. El objetivo de la presente revisión es fomentar el conocimiento biográfico y la época histórica en la cual tomó lugar su quehacer médico o laboral, para así profundizar aspectos de la historia de la medicina. Keywords:Intensive Care; biography; eponyms; etymology; medicine history AbstractEponyms reflect the history of medicine, diseases, and doctors in their time. Their use is controversial, presenting supporters and detractors. However, the use of eponyms persist in the modern medical language in the Intensive Care Units and includes some frequently used ones such as Foley, Seldinger, Down, Macintosh, Magill, Ringer, Yankauer, Doppler, and French. The objective of this review is to promote biographical knowledge and the historical period in which its medical use took place, in order to deepen aspects of medicine history.

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“…6 It was shown that healthy individuals could tolerate infusion of lactate with resulting concentrations up to 50 mMol/L and clear it with a half-time of approximately 20 minutes. 7,8 In patients suffering from hemorrhagic shock, infusion of lactate-based solutions resulted in improvement of vital signs, improvement of metabolic acidosis, and rapid clearance of lactate. Interestingly, in two patients with preexisting liver disease, lactate clearance was delayed.…”

Section: Lactic Acidosismentioning

confidence: 99%