Studies in the hydrolysis of metal ions

Mahapatra, Santanu; Subrahmanya, R. S.

doi:10.1007/bf03049535

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…For Zn(II) only the hydrolysis corresponding to Log 10 β 10 - 2 = −16.08 could be determined. These constants agree in order of magnitude with literature data ( , ). Because of the extensive formation of the metal hydroxides, for Cu(II) and Zn(II) it was not possible to obtain constants for all hydrolysis steps ( , ); nevertheless, the determined constants appear to be sufficient to represent a reasonable working model of the system.…”

Section: Resultssupporting

confidence: 90%

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Seifert

Krause

Gloe

et al. 2004

J. Agric. Food Chem.

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Although the Maillard reaction between proteins and carbohydrates is of central importance for food processing and in vivo processes, only little is known about changes of the metal-binding properties induced by protein glycation. The purpose of this study was to examine the complex formation of the quantitatively important peptide-bound Maillard reaction products (MRPs) N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine with the biologically relevant metal ions copper(II) and zinc(II). The MRPs were synthesized as the N(alpha)-hippuryllysine derivatives in order to block the coordination function of the alpha-amino group. Stability constant measurements were performed in aqueous solution using pH potentiometry. N(alpha)-Hippuryl-N(epsilon)-fructoselysine forms moderate Cu(II) complexes (Log(10) K(1) = 5.8; Log(10) K(2) = 4.0) but fails to form any complexes with Zn(II). N(alpha)-Hippuryl-N(epsilon)-carboxymethyllysine gives slightly stronger complexes with Cu(II) (Log(10) K(1) = 7.3; Log(10) K(2) = 6.3), but again no complexation with Zn(II) was observed. These results show that post-translational modification of proteins by carbohydrates leads to the formation of new coordination centers for metal ions within a protein chain. Further studies are necessary to clarify the consequences of this phenomenon in terms of protein quality and physiological processes.

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Section: Resultssupporting

confidence: 90%

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Seifert

Krause

Gloe

et al. 2004

J. Agric. Food Chem.

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“…The present critical evaluation indicates that log 10 *K 1°= -7.95 (log 10 K 1°= 6.05) and log 10 *K 2°= -8.2 5 (log 10 K 2°= 5.7 5 ), which is the normal sequence for metal ion hydrolysis reactions and Cu 2+ complex formation constants. In contrast, [67MSb] and [68SMd] reported log 10 K 2 > log 10 K 1 , i.e., -log 10 *K 1 > -log 10 *K 2 . This unexpected relationship suggests a change in coordination number at the second hydrolysis step, which seems unlikely for Cu II .…”

Section: Formation Of Cu(oh) 2 (Aq)mentioning

confidence: 94%

“…Higher values of log 10 K 2 may result from the presence of a Cu II -hydroxy colloid at pH > 7 [80PKb] and/or polynuclear species. The values of [67MSb] and [68SMd] are therefore rejected.…”

Section: Formation Of Cu(oh) 2 (Aq)mentioning

confidence: 99%

Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands. Part 2. The Cu²⁺—OH^‐, Cl^‐, CO₃^2‐, SO₄^2‐, and PO₄^3‐ Systems (IUPAC Technical Report)

et al. 2007

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First Transition Series Metals

2016

Hydrolysis of Metal Ions

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Studies in the hydrolysis of metal ions

Cited by 10 publications

References 8 publications

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands. Part 2. The Cu²⁺—OH^‐, Cl^‐, CO₃^2‐, SO₄^2‐, and PO₄^3‐ Systems (IUPAC Technical Report)

First Transition Series Metals

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Studies in the hydrolysis of metal ions

Cited by 10 publications

References 8 publications

Metal Complexation by the Peptide-Bound Maillard Reaction Products Nε-Fructoselysine and Nε-Carboxymethyllysine

Metal Complexation by the Peptide-Bound Maillard Reaction Products Nε-Fructoselysine and Nε-Carboxymethyllysine

Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands. Part 2. The Cu2+—OH‐, Cl‐, CO32‐, SO42‐, and PO43‐ Systems (IUPAC Technical Report)

First Transition Series Metals

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About

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Metal Complexation by the Peptide-Bound Maillard Reaction Products N^ε-Fructoselysine and N^ε-Carboxymethyllysine

Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands. Part 2. The Cu²⁺—OH^‐, Cl^‐, CO₃^2‐, SO₄^2‐, and PO₄^3‐ Systems (IUPAC Technical Report)