Studies in the Home Treatment of Streptococcal Disease

Mohler, Daniel N.; Wallin, David; Dreyfus, Edward G.

doi:10.1056/nejm195506302522604

Cited by 104 publications

(7 citation statements)

References 10 publications

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“…Two studies shed some light on this issue. Mohler and associates 31 found that the 3 most eommon reasons given for not taking penicillin were that the patient felt weH (37 per cent), eardessness (27 per cen t ), and insufficient money (17 per cent). Another 19 per cent cither simply refused or misunderstood the purpose of tre1tment.…”

Section: Volume 13 Number6mentioning

confidence: 99%

The drug defaulter

Blackwell

1972

Clin Pharma and Therapeutics

163

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There have been over 50 studies on patients who fail to take their medications “as directed.” The patients in these studies usually required chronic maintenance therapy for conditions including tuberculosis, schizophrenia, anemia, rheumatoid arthritis, and other diseases seen in general practice. Attention has also been paid to the special problems posed by geriatric patients and by children who depend for medication on their parents.

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Section: Volume 13 Number6mentioning

confidence: 99%

The drug defaulter

Blackwell

1972

Clin Pharma and Therapeutics

163

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“…In the 19th century, Robert Koch, the father of modern bacteriology, was critical of patients with tuberculosis who did not adhere to strategies to reduce infection. In 1955, soon after the introduction of antibiotics, it was observed that approximately one third of patients did not complete a 1-week course of oral penicillin for acute pharyngitis or otitis media 2. A recent national guideline concluded that between a third and one half of medicines that are prescribed for long-term conditions are not taken by patients as recommended by the prescriber 3.…”

Section: Introductionmentioning

confidence: 99%

Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies

Haddad¹,

Brain²,

Scott³

2014

PROM

451

418

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Nonadherence with medication occurs in all chronic medical disorders. It is a particular challenge in schizophrenia due to the illness’s association with social isolation, stigma, and comorbid substance misuse, plus the effect of symptom domains on adherence, including positive and negative symptoms, lack of insight, depression, and cognitive impairment. Nonadherence lies on a spectrum, is often covert, and is underestimated by clinicians, but affects more than one third of patients with schizophrenia per annum. It increases the risk of relapse, rehospitalization, and self-harm, increases inpatient costs, and lowers quality of life. It results from multiple patient, clinician, illness, medication, and service factors, but a useful distinction is between intentional and unintentional nonadherence. There is no gold standard approach to the measurement of adherence as all methods have pros and cons. Interventions to improve adherence include psychoeducation and other psychosocial interventions, antipsychotic long-acting injections, electronic reminders, service-based interventions, and financial incentives. These overlap, all have some evidence of effectiveness, and the intervention adopted should be tailored to the individual. Psychosocial interventions that utilize combined approaches seem more effective than unidimensional approaches. There is increasing interest in electronic reminders and monitoring systems to enhance adherence, eg, Short Message Service text messaging and real-time medication monitoring linked to smart pill containers or an electronic ingestible event marker. Financial incentives to enhance antipsychotic adherence raise ethical issues, and their place in practice remains unclear. Simple pragmatic strategies to improve medication adherence include shared decision-making, regular assessment of adherence, simplification of the medication regimen, ensuring that treatment is effective and that side effects are managed, and promoting a positive therapeutic alliance and good communication between the clinician and patient. These elements remain essential for all patients, not least for the small minority where vulnerability and risk issue dictate that compulsory treatment is necessary to ensure adherence.

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“…Most of these studies used either surveys or interviews, aiming to quantify patients' answers to standardized questions to determine the most prominent causes of non-compliance (2,3,8,15,16). Spaeth (16), for example, conducted extensive interviews where he correlated demographic data, interview responses and visual function statistics.…”

Section: Introductionmentioning

confidence: 99%

Causes Of Non-Compliance With Drug Regimens In Glaucoma Patients: A Qualitative Study

Taylor

Galbraith

Mills

2002

Journal of Ocular Pharmacology and Therapeutics

194

155

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The purpose of this study was to gain insights into why patients are not compliant with their glaucoma medications. Patients were recruited from lists provided by two ophthalmologists. Each patient had seen a minimum of two ophthalmologists for their glaucoma, and was taking at least two topical medications for glaucoma. Qualitative methodology was utilized, including two focus groups and eleven in-depth interviews in patients' homes. The results showed that forgetfulness was the number one reported reason for non-compliance. Patients did not claim to be non-compliant specifically because of side effects, but they did complain about them. Communication between physicians and patients is a key factor in compliance for glaucoma patients. Specifically, patients would like their physicians to teach them how to instill their eye drops, tell them about new/alternate medications and procedures as they become available, and offer new ways to make their regimen easier. Patients often do not tell their physician if they experience a side effect unless it is intolerable to them, yet they do realize the seriousness of glaucoma, and the consequences of not following their doctor's orders. Finally, while cost was not a reported deterrence to compliance, some patients would prefer less expensive alternatives.

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Studies in the Home Treatment of Streptococcal Disease

Cited by 104 publications

References 10 publications

The drug defaulter

The drug defaulter

Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies

Causes Of Non-Compliance With Drug Regimens In Glaucoma Patients: A Qualitative Study

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