Studies in Protein Intoxication

Shattuck, Howard F.

doi:10.1001/archinte.1917.00090020008002

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship of the cutaneous manifestations of serum disease to anaphylaxis is especially well supported by the studies of C. W. Wells (88) on the precipitin content of the blood of patients who have received diphtheria antitoxin, for he found that in several persons who developed such manifestations the precipitin titer fell to rise again when the rash faded, as if the precipitin had been bound in the skin and thus caused a local anaphylactic reaction. Also, Weil(31) observed in human serum sickness a fall in blood pressure and a decrease in the coagulability of the blood (89), thus adding to the resemblance of this condition to true anaphylactic reactions.…”

Section: Desensitization and Anti-anaphylaxismentioning

confidence: 99%

The Present Status of the Problems of Anaphylaxis

Wells¹

1921

Physiological Reviews

View full text Add to dashboard Cite

Section: Desensitization and Anti-anaphylaxismentioning

confidence: 99%

The Present Status of the Problems of Anaphylaxis

Wells¹

1921

Physiological Reviews

View full text Add to dashboard Cite

Serum Sickness and Anaphylaxis

Kojis¹

1942

Am J Dis Child

View full text Add to dashboard Cite

Blood Examinations in Hay Fever Patients During Acute Allergic Shock

Castberg¹,

Schwartz²

1948

Allergy

View full text Add to dashboard Cite

Allergic shock in tnan comes unexpectedly in most cases, or at any rate under conditions prohibiting exact examination of the composition of the blood while the shock lasts; as a result, our knowledge of any changes there may be in the state of the blood during allergic shock rests upon a relatively slender foundation.In animals, anaphylactic shock is generally considered to be analogous to allergic shock in man; the pathogenesis is assumed to be the same in both reactions: an antigen-antibody reaction liberates a histamine-like substance which thereupon induces the local and general symptoms (4, 6). It should be observed, however, that in anaphylactic shock the symptoms may vary considerably from one kind of animal to another, just as in man the allergic shock has no uniform symptomatology. Finally, the liberation of histamine (or H-substance) will not suffice as an explanation of all symptoms, and it is assumed that other humoral intermediaries (heparine, acetylcholine) are also active.In anaphylactic shock (in animals) there occurs a sudden change in the permeability of the capillaries and in the tone of the smooth muscles in various organs; this rapidly involves changes in the blood pressure, respiration and the chemical and cytological composition of the blood.For example, there may be a greater or smaller fall in the blood pressure (7), haemoconcentration, together with a decrease in the number of leucocytes and thrombocytes (5,6,8,9, 12,20, 21,22,28,29), and the coagulation time is prolonged (up to

show abstract

Studies in Protein Intoxication

Cited by 5 publications

References 0 publications

The Present Status of the Problems of Anaphylaxis

The Present Status of the Problems of Anaphylaxis

Serum Sickness and Anaphylaxis

Blood Examinations in Hay Fever Patients During Acute Allergic Shock

Contact Info

Product

Resources

About