Studies in prediabetes. Insulin response to oral glucose, intravenous tolbutamide and rapid intravenous glucose infusion in genetic prediabetics

Serrano-Rı́os, Manuel; Ramos, F.; J.L.Rodriguez-Miñon,; Vivanco, F. Hernandez

doi:10.1007/bf01212071

Cited by 35 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding was previously observed by us (10) and by others (12,14,26,27), whereas a decreased (28)(29)(30) or increased (13) insulin response to oral glucose has been less frequently reported. These divergent results in relation to ours may be due to the different ethnic groups studied (13) or to a small and specific group of prediabetic individuals that may have included future type 1 diabetic patients (28)(29)(30).…”

Section: Discussionsupporting

confidence: 74%

“…Many studies have evaluated insulin release by an intravenous glucose stimulus in offspring of type 2 diabetic patients who showed normal glucose tolerance. Although most of these studies found lower insulin secretion (14,31,32), many authors did not observe any difference in relation to control individuals (16,33,34), and in some cases increased insulin release was reported (15,35).…”

Section: Discussionmentioning

confidence: 99%

“…However, in the study by Eriksson et al (12), the subjects were not well-matched, and some of the participants in the study by Gulli et al (13) who were Mexican-Americans probably had impaired glucose tolerance. With a less sensitive technique, i.e., the acute glucose infusion test associated with mathematical models, the results have also been controversial; ß-cell dysfunction (14), decreased insulin sensitivity (15), or no defect (16) has been observed. It should be noted, however, that in the study by Warram et al (15) probands were markedly obese compared to the controls and none of these studies evaluated the appropriateness of ß-cell function in relation to insulin sensitivity (17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients

Pimenta

Santos

Cruz

et al. 2003

Braz J Med Biol Res

View full text Add to dashboard Cite

To identify early metabolic abnormalities in type 2 diabetes mellitus, we measured insulin secretion, sensitivity to insulin, and hepatic insulin extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree relatives of type 2 diabetic patients (FH+). Each individual was matched for sex, age, weight, and body fat distribution with a person without history of type 2 diabetes (FH-). Both groups were submitted to a hyperglycemic clamp procedure (180 mg/dl). Insulin release was evaluated in its two phases. The first was calculated as the sum of plasma insulin at 2.5, 5.0, 7.5, and 10.0 min after the beginning of glucose infusion, and the second as the mean plasma insulin level in the third hour of the clamp procedure. Insulin sensitivity index (ISI) was the mean glucose infusion rate in the third hour of the clamp experiment divided by the mean plasma insulin concentration during the same period of time. Hepatic insulin extraction was determined under fasting conditions and in the third hour of the clamp procedure as the ratio between C-peptide and plasma insulin levels. FH+ individuals did not differ from FH-individuals in terms of the following parameters [median (range)]: a) first-phase insulin secretion, 174 (116-221) vs 207 (108-277) µU/ml, b) second-phase insulin secretion, 64 (41-86) vs 53 (37-83) µU/ml, and c) ISI,.0) mg kg -1 min -1 /µU ml -1 . Hepatic insulin extraction in FH+ subjects was similar to that of FH-ones at basal conditions (median, 0.27 vs 0.27 ng/µU) and during glucose infusion (0.15 vs 0.15 ng/µU). Normal glucose-tolerant Brazilian FH+ individuals well-matched with FH-ones did not show defects of insulin secretion, insulin sensitivity, or hepatic insulin extraction as tested by hyperglycemic clamp procedures.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients

Pimenta

Santos

Cruz

et al. 2003

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…glucose preceded the "abrupt" clinical onset of type I diabetes in monozygotic twins and triplets. 16 The responses to various p-cell secretagogues described in this report indicate that there is a more severe p-cell insensitivity to i.v. glucose compared with other secretagogues, i.e., tolbutamide, arginine, and glucagon (although responses to these other secretagogues were quantitatively decreased, and to oral glucose was also qualitatively abnormal, being sluggish).…”

Section: Discussionmentioning

confidence: 90%

Differential Sensitivity to β-Cell Secretagogues in “Early,” Type I Diabetes Mellitus

Ganda¹,

et al. 1984

View full text Add to dashboard Cite

The insulin secretory response to various beta-cell secretagogues was studied in four children (ages 11, 11, 12, and 10 yr) in "early" stages or remission of type I diabetes mellitus. One child was an anti-islet antibody positive monozygotic twin of a type I diabetic subject, two children had impaired glucose tolerance and elevated levels of Ia-positive T-cells, and the fourth was in remission (off insulin) of type I diabetes 6 mo after immunotherapy. The peak first-phase (0-10 min) insulin increment after intravenous (i.v.) glucose was negligible in each patient, whereas the peak responses to i.v. glucagon, tolbutamide, arginine, and oral glucose ranged between 10% and 43% of median responses in normal control subjects. The rank order of response to a variety of secretagogues was remarkably similar in all four subjects: i.v. arginine greater than i.v. glucagon greater than oral glucose greater than i.v. tolbutamide greater than i.v. glucose. These studies indicate that a "functional" beta-cell defect, namely a complete loss of response to i.v. glucose and a partial loss to other secretagogues, exists in type I diabetic patients before complete beta-cell destruction. This alteration in beta-cell responsiveness probably underlies our prior observation of slowly progressive loss of i.v.-glucose-induced insulin release in islet cell antibody-positive siblings to type I diabetic subjects.

show abstract

“…It is then necessary to look for a more sensitive and perhaps more basic marker of diabetes mellitus. In this respect some have stressed the importance of a decreased insulin secretion [27,28,29,30] and an increased growth hormone release [31,32]; others refer to capillary basal membrane thickening [33]. However, these findings have not been confirmed [34,35,36,37] and the interpretations have also been criticized [38,39].…”

Section: Discussionmentioning

confidence: 99%

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

Radder

Terpstra

1975

Diabetologia

View full text Add to dashboard Cite

Summary. 88 of 137 offspring of 22 adult onset diabetic couples were subjected to an oral glucose tolerance test (G.T.T.); 35 were found to have a diabetic G.T.T. As 8 were already known as diabetics, 43 of 96 offspring (45Yo) were found to have diabetes mellitus. Neither the data pertaining to the parents, such as family history, treatment of diabetes or obstetric history, nor the data pertaining to the offspring, such as sex, age, parity or course of pregnancy, could be related to the incidence of diabetes in the offspring. It was noted however, that overweight female, but not male, offspring are more likely to develop diabetes than those who are not overweight (p < 0.05).

show abstract

Studies in prediabetes. Insulin response to oral glucose, intravenous tolbutamide and rapid intravenous glucose infusion in genetic prediabetics

Cited by 35 publications

References 23 publications

Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients

Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients

Differential Sensitivity to β-Cell Secretagogues in “Early,” Type I Diabetes Mellitus

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

Contact Info

Product

Resources

About