Studies in neural tube defects II. Pathologic findings in a prospectively collected series of anencephalics

Melnick, Michael; Myrianthopoulos, Ntinos C.

doi:10.1002/ajmg.1320260406

Cited by 90 publications

(22 citation statements)

References 19 publications

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“…This research identified a predominantly young population, which was not significant in other studies (11)(12)(13) . Regarding the duration of pregnancy, preterm birth found in other studies ranged from 50% to 53% meeting the results of this survey, which shows a 55% incidence of this type of delivery.…”

Section: Discussioncontrasting

confidence: 63%

“…Regarding the duration of pregnancy, preterm birth found in other studies ranged from 50% to 53% meeting the results of this survey, which shows a 55% incidence of this type of delivery. The postterm pregnancy had a lower incidence (3.8%) than that observed in other studies, whose numbers ranged between 10% and 17% (11)(12)(13) . Our study also obser ved the occurrence of 6.4% of spontaneous pregnancy loss, which was not found or not observed in other studies.…”

Section: Discussioncontrasting

confidence: 63%

“…The prevalence of polyhydramnios, with a wide variation ranging from 27% to 90%. If we look alone, in our study this was present in 50% of cases (11)(12)(13) . Authors, in their studies found an association between polyhydramnios and congenital anomalies in 81.1% of pregnancies analyzed (14) .…”

Section: Resultsmentioning

confidence: 48%

“…In another study it was observed that the chance of oligohydramnios in the pregnancy is five times higher when there are congenital anomalies (15) . As for the fetal death, data in the literature range from 7% to 50% of intra uterine fetal death in anencephaly (11)(12)(13) . In our study, among the cases of anencephaly this figure was over 23%, and overall, counting all the anomalies, 20%.…”

Section: Resultsmentioning

confidence: 99%

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Complicações obstétricas em gestações com feto portador de anomalia incompatível com a sobrevida neonatal

Sala¹,

Abrahão

2010

Acta paul. enferm.

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Objective: To describe the most common obstetric complications encountered during periods of pregnancy, childbirth and puerperium, in pregnancies with fetuses that presented anomalies incompatible with life. Methods: This is a descriptive study, which assessed 78 medical charts of patients in the Prenatal Fetal Medicine Division of the Federal University of São Paulo; the women gave birth at the same institution, between 2000 and 2006. Results: The major obstetric complications identified were: variation in the volume of amniotic fluid (68%), miscarriage, pre-term labor and prolonged pregnancy were present in 6.4%, 55.1% and 3.8% of pregnancies, respectively; intrauterine fetal death, 17.9%, abruptio placenta occurred in 6.4% and hysterectomy in 2.6%. Conclusion: These results suggest that fetus with severe anomalies presented an increase of the risk for pregnancies, which demonstrates the need for expert evaluation in each case. Descriptors: Pregnancy complications; Pregnancy, high-risk; Congenital abnormalities; Genetic counseling RESUMO Objetivo: Descrever as complicações obstétricas mais comuns encontradas nos períodos gestacional, parto e puerpério imediato de gestantes com fetos portadores de anomalias incompatíveis com a vida. Métodos: Estudo descritivo, onde avaliou-se 78 prontuários de pacientes atendidas no pré-natal da Disciplina de Medicina Fetal da Universidade Federal de São Paulo que tiveram partos nessa mesma instituição, entre 2000 e 2006. Resultados: As principais complicações obstétricas identificadas foram:variação do volume de líquido amniótico em 68%; abortamento, parto pré-termo e a gravidez prolongada estiveram presentes em 6,4%, 55,1% e 3,8% das gestações, respectivamente; óbito fetal intra-uterino em 17,9%; descolamento prematuro da placenta ocorreu em 6,4% e histerectomia em 2,6%. Conclusão: Estes resultados sugerem aumento de risco materno em gestações com fetos portadores de anomalias graves, fato que demonstra necessidade de avaliação especializada caso a caso. Descritores: Complicações na gravidez; Gravidez de alto risco; Anomalias congênitas; Aconselhamento genético RESUMEN Objetivo: Describir las complicaciones obstétricas más comunes encontradas en los períodos de gestación, parto y puerperio inmediato de embarazadas con fetos portadores de anomalías incompatibles con la vida. Métodos: Se trata de un estudio descriptivo, que evaluó 78 fichas médicas de pacientes atendidos en el prenatal de la Disciplina de Medicina Fetal de la Universidad Federal de Sao Paulo que tuvieron partos en esa misma institución, entre 2000 y 2006. Resultados: Las principales complicaciones obstétricas identificadas fueron: variación del volumen de líquido amniótico en 68%; abortamiento, parto pre-término y embarazo prolongado estuvieron presentes en 6,4%, 55,1% y 3,8% de las gestaciones, respectivamente; muerte fetal intra-uterina en 17,9%; desprendimiento prematuro de la placenta ocurrió en 6,4% e histerectomía en 2,6%. Conclusión: Éstos resultados sugieren un aumento del riesgo materno en gest...

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Section: Discussioncontrasting

confidence: 63%

Section: Discussioncontrasting

confidence: 63%

Section: Resultsmentioning

confidence: 48%

Section: Resultsmentioning

confidence: 99%

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Complicações obstétricas em gestações com feto portador de anomalia incompatível com a sobrevida neonatal

Sala¹,

Abrahão

2010

Acta paul. enferm.

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“…Regardless of numbers, the migratory ability of NC cells depends on down-regulation of N-CAM (Thiery et al,, 1982;Bronner-Fraser et al, 1992) and adhesive interactions between themselves and with the 0 1994 WILEY-LISS, INC extracellular matrix (Boucaut et al, 1984;Thiery et al, 1986;Noden, 1988). Craniofacial abnormalities observed with or without an associated neural tube defect may thus be related to altered NC migration into the presumptive facial region during early embryogenesis (Johnston, 1975;Johnston and Bronsky, 1991;Melnick and Myrianthopoulos, 1987). For example, defective NC cell migration from the forebrain neural folds results in frontonasal mesenchyme deficiencies and precludes normal primary palate formation (Johnston, 1975).…”

Section: Introductionmentioning

confidence: 99%

Effect of in ovo retinoic acid exposure on forebrain neural crest: In vitro analysis reveals up‐regulation of N‐CAM and loss of mesenchymal phenotype

Shankar

Chuong

Jaskoll

et al. 1994

Developmental Dynamics

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In a prior study of in ovo exogenous retinoic acid (RA) exposure, we observed a prolonged expression of cell surface N-CAM in cranial neural crest (NC) cells exhibiting migratory failure. In the present studies, we employed an experimental strategy in which embryos were first exposed to exogenous RA in ovo and incubated for 45-60 hr; this was followed by extirpation and in vitro culturing of these same RA-exposed cranial neural tubes. NC cell outgrowth from the explant was assayed, as was the immunohistochemical localization of HNK-1 and N-CAM antigens. In RA-exposed explants, the size of the NC cell outgrowths were comparable to controls. However, almost all NC cells lost their mesenchymal phenotype and were arranged in an "epithelioid" pattern of tightly packed polygonal cells that expressed N-CAM at adjacent cell boundaries. By contrast, control NC cells were flattened and multipolar in shape and expressed HNK-1, rarely co-expressing N-CAM. These observations indicate that RA modulates NC cell N-CAM expression and microanatomical phenotype, a finding consistent with prior in ovo studies of RA-exposure. Several possible explanations are considered. o

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The Use of Anencephalic Infants as Organ Sources

Shewmon

Capron²,

Peacock³

et al. 1989

JAMA

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The recent abandonment of the only active US protocol for harvesting organs from anencephalic "donors" indicates both the practical and the ethical problems inherent in such an effort. Various data suggest that surprisingly few such organs would actually end up benefiting other children. Attempts to revise either the Uniform Anatomical Gift Act or the Uniform Determination of Death Act to allow organ removal from spontaneously breathing anencephalic infants face major ethical objections. Even if this posed no ethical problem in theory, the ultimate harm to society would not be offset by the good of the few surviving recipients of these organs. Furthermore, providing anencephalic infants with intensive care would tend to preserve the brain stem as effectively as the other organs, predictably rendering the occurrence of brain death unlikely. Thus, despite the great need for newborn organs, anencephalic infants are not as attractive a source as some had hoped.

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Studies in neural tube defects II. Pathologic findings in a prospectively collected series of anencephalics

Cited by 90 publications

References 19 publications

Complicações obstétricas em gestações com feto portador de anomalia incompatível com a sobrevida neonatal

Complicações obstétricas em gestações com feto portador de anomalia incompatível com a sobrevida neonatal

Effect of in ovo retinoic acid exposure on forebrain neural crest: In vitro analysis reveals up‐regulation of N‐CAM and loss of mesenchymal phenotype

The Use of Anencephalic Infants as Organ Sources

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