Studies in Man on the Relationship of Adrenergic Correlates to Pressor Responsivity

Abstract

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Analysis of the Variability of Blood Pressure, Pulse Rate, and Catecholamine Responsivity in Identical and Fraternal Twins

“…In our previous study, it was shown that these biochemical measurements did not correlate with the cardiovascular response, but rather seemed to relate to the individual's concept or perception of the stimulus. 3 Other investigators have shown similar variation in steroid and FFA levels which relate to such aspects of the stimulus or situation as its "novelty." 11 '-14 Although the relationship of the biochemical measurements to the meaning of the stimulus is not established in the present study, the former again fail to correlate with the cardiovascular responses.…”

“…Next, apparatus was attached for recording blood pressure and pulse rate by indirect techniques, as previously described. 3 The subject then rested for 15 min., following which two stimuli were administered, with another 15-min. rest period between them.…”

“…VMA was measured by the method of Sunderman et al; s and norepinephrine (NE) and epinephrine (E) by differential fluorometry of the trihydroxyindoles as described in our previous studies. 3 Excretion was expressed as nanograms (for NE and E) and micrograms (for VMA) per milligram of urinary creatinine. * FFA in the plasma were titrated according to the method of Trout et al and expressed as microequivalents per liter.…”

“…2 ' 4 Similarly, recent experiments from this laboratory have shown that a number of chemical measurements of autonomic nervous system activity correlated with environmental and psychological circumstances rather than with the pressor response. 3 The above findings suggested the following hypothesis, which could be tested in normotensive twins:…”

Effects of practolol on pressor responses to noxious stimuli in hypertensive patients

“…21 The stimuli were administered at 10 to 15 minute intervals after an initial rest period of at least 15 minutes. The sequence of administration of the stimuli was varied randomly from patient to patient and from one testing session to the other within the same patient.…”