Studies in Hypersensitivity to Light

Sulzberger, Marion B.; Baer, Rudolf L.

doi:10.1038/jid.1945.32

Cited by 34 publications

(6 citation statements)

References 10 publications

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“…A reverse passive transfer test was also developed, requiring irradiation of the recipient's skin prior to injection of SU serum. Subsequent development of erythema, wheal and flare reactions at the recipient's injection site were interpreted as confirmation of the transfer of an allergic antibody responsible for the development of SU 14,16,17 . In combination with the action spectra of SU patients, these passive transfer experiments were subsequently used by Harber et al to classify SU into six subtypes in which the pathogenesis was mediated by an allergic antibody or by other uncharacterized non‐allergic mechanisms (Table 1a).…”

Section: Solar Urticaria: Classic Perspectives On Its Pathogenesismentioning

confidence: 99%

Pathogenesis of solar urticaria: Classic perspectives and emerging concepts

McSweeney

Sarkany

Fassihi

et al. 2021

Experimental Dermatology

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Solar urticaria is a rare, immunologically mediated photodermatosis in which activation of cutaneous mast cells is triggered by specific wavelengths of solar electromagnetic radiation. This manifests clinically as the rapid development of cutaneous itch, erythema and wheal formation after several minutes of sun exposure. Disease mechanisms in solar urticaria remain incompletely elucidated and there have been few recent investigations of its pathobiology. Historic passive transfer experiments performed during the twentieth century provide support for a ‘photoallergy’ model of disease pathogenesis, wherein molecular alteration of a putative chromophore by solar electromagnetic radiation produces mast cell activation via an IgE‐dependent mechanism. However, this model does not account for several observations made during passive transfer experiments nor does it explain a range of subsequent clinical and photobiological observations made in solar urticaria patients. Furthermore, increased understanding of the molecular dynamics underpinning cutaneous mast cell responses highlights the need to reformulate our understanding of solar urticaria pathogenesis in the context of this contemporary scientific landscape. In this review, we discuss the current understanding of solar urticaria pathogenesis and, by incorporating recent scientific and clinical observations, develop new hypotheses to drive future investigation into this intriguing disorder.

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Section: Solar Urticaria: Classic Perspectives On Its Pathogenesismentioning

confidence: 99%

Pathogenesis of solar urticaria: Classic perspectives and emerging concepts

McSweeney

Sarkany

Fassihi

et al. 2021

Experimental Dermatology

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“…That solar urticaria is due to an antigen–antibody reaction and that the antigen is produced in the skin after solar irradiation have been known for half a century. 13 An intradermal injection of serum from an individual with solar urticaria can passively transfer the condition to a normal individual, 10 , 16 , 17 , 21 , 75 although this does not always occur. Heating the serum may destroy its capacity for passive transfer.…”

Section: Pathogenesismentioning

confidence: 99%

“…This was confirmed by other authors. 13 In the meantime, several publications reported that those areas of the skin usually exposed to solar irradiation, such as the face and the hands, were less sensitive than those usually covered. 5 , 8 This proved to be the basis of the desensitization approach developed more than half a century later.…”

mentioning

confidence: 99%

“…4 Action spectra were thus determined already in the early research using artificial light sources and different types of filter. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Although wavelengths between 300 and 800 nm and even longer 12,19 have been reported, the action spectrum for most patients is between 300 and 500 nm. In 1942, Rajka 10 reported that solar urticaria could be passively transferred to normal volunteers by an intradermal injection of serum from a person with solar urticaria.…”

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confidence: 99%

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Solar urticaria: the annoying photodermatosis

Roelandts

Ryckaert

1999

Int J Dermatology

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“…Passive [5,6] and reverse passive [7| transfer tests were attempted on one of the authors (Y.K.. normal subject). In the passive transfer test.…”

Section: Serum Testsmentioning

confidence: 99%

Drug-Induced Solar Urticaria due to Repirinast

Kurumaji¹,

Shono²

1994

Dermatology

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We describe the first case of drug-induced solar urticaria due to repirinast, an antiallergic drug developed and introduced into the market in Japan in 1987. The patient was a 72-year-old woman who had been on repirinast for 1 year and 8 months. She developed urticaria immediately after an irradiation with 1.5 J/ cm of UVA, and the provocation test confirmed that repirinast was responsible for the urticarial reaction. The action spectrum of the urticarial reaction was deduced to be 320–350 nm. Passive and reverse passive transfer test results were both negative. However, intradermal injection of patient serum, obtained while she was on repirinast and irradiated in vitro with UVA, demonstrated positive reactions both in the patient and in a normal volunteer. Our findings suggest that nonallergic mechanisms are involved in the reaction. However, the rarity of the phenomenon also suggests an association with some allergic mechanisms.

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Studies in Hypersensitivity to Light

Cited by 34 publications

References 10 publications

Pathogenesis of solar urticaria: Classic perspectives and emerging concepts

Pathogenesis of solar urticaria: Classic perspectives and emerging concepts

Solar urticaria: the annoying photodermatosis

Drug-Induced Solar Urticaria due to Repirinast

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