Studies in Dieckmann cyclization and utilization of the products in the synthesis of steroids

Abstract

THE studies on Dieckmann cyclization of various polyesters and utilization of the resulting products for the synthesis of steroids constitute a part of major research activities of our laboratory covering a long period. Our first attempt consisted in employing the fl-keto ester, 2,3-dicar-* The main sul ject-matter of this article was presented at the post-IUPAC meeting held in February, 1972 at the National Chemical Laboratory, Poona-8. India, and later it was presented in greater details with added materials as a series of lectures at the Kurukshctra University in

Total Synthesis of Norsampsones A and B, Garcinielliptones N and O, and Hyperscabrin A

“…Dieckmann condensation and variants thereof are powerful reactions to produce cyclic β-keto esters . The decarbonyl PPAPs that feature at least a dicarbonyl moiety are shown in Scheme , which revealed that a Dieckmann condensation with ketone or ester as the nucleophile could be applied.…”