An automated distillation sequencing system (DSEQSYS) is presented, which consists of three components: a controlprogram, a fuzzy heuristicsynthesis program, and a process simulator. DSEQS YS, when applied to problems previously reported in the literature, overcomes some of the disadvantages of using heuristics or mathematical programming alone. DSEQSYS can address problems involving nonsharp separations, nonideal chemical behauior, and conflicting heuristics. A simple approach for converting the traditional separation heuristics into corresponding fuzzy heuristics is also demonstrated.