Studien �ber den Ablauf der Alkoholintoxikation unter besonderer Ber�cksichtigung der pharmakopsychologischen Beziehungen in der Resorptionsphase bei Alkoholgew�hnten

Bschor, F

doi:10.1007/bf00664807

Cited by 13 publications

(7 citation statements)

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“…Psychomotor and cognitive impairment following acute ethanol intoxication is greater during the ascending than the descending phase of the plasma ethanol curve (Mellanby 1919;Eggleton 1941;Goldberg 1943;Alha 1951;Bschor 1951. More recently, ethanol-induced changes in mood states have been shown to be biphasic; reports of euphoria usually occur during the ascending limb of the plasma ethanol curve, while dysphoric reactions often occur during the descending limb (Smith et al 1975;Freed 1978 ;Russell and Mehrabian 1975;Hartocollis 1962;Jones 1973;Babor et al 1983).…”

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confidence: 99%

Instrumental analysis of ethanol-induced intoxication in human males

1986

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A study was conducted to assess subjective reports of intoxication during the ascending phase of the plasma ethanol curve. Eighteen male social drinkers were divided into three groups and were given either placebo, 0.347 g/kg ethanol or 0.694 g/kg ethanol under double-blind conditions. Subjects reported levels of intoxication both instrumentally, by moving a joystick device, and verbally using an 11-point self-rating scale. Compared to placebo, ethanol produced significantly higher verbal self-rating scores, but there were no differences in the scores between the low- and high-dose ethanol groups. Instrumental responses of ethanol effects did, however, distinguish between the two ethanol treatments. All subjects who received ethanol reliably detected its effects when plasma ethanol levels reached 32 mg/dl, but only the subjects who received the high dose reported episodes of intense well-being or euphoria. Ethanol-induced euphoria occurred while plasma ethanol levels were rapidly rising, and was characterized by multiple, paroxysmal episodes that typically lasted about 3 min each. This study demonstrated that a continuously available instrumental response provided sensitive and reliable measures of rapidly changing behavioral states associated with ethanol-induced intoxication.

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confidence: 99%

Instrumental analysis of ethanol-induced intoxication in human males

1986

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“…Goldberg assumed a similar effect of alcohol on the motoric and sensor system, and psyche. He concluded that complex actions are appropriate to distinguish between the effects of alcohol resorption and elimination [ 18 , 19 ]. The course which needed to be completed posed various challenges to the sense of balance, motoric skills and the need of high comprehension.…”

Section: Discussionmentioning

confidence: 99%

“…From a toxicological point of view, it is easily understandable that fast BAC changes lead to more signs of failure than slow BAC changes: It was previously theorized that due to the strong blood flow to the brain, the central nervous effects of alcohol become apparent early [ 19 , 20 ]. Our study design leaned towards a “realistic drinking event” (between 2:22 and 4:41 h to reach approx.…”

Section: Discussionmentioning

confidence: 99%

The “Mellanby effect” in alcoholised e-scooter drivers

et al. 2022

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Purpose Several studies tried to discuss and clarify the so-called Mellanby effect: Similar blood alcohol concentrations (BACs) supposedly lead to more signs of impairment in the phase of alcohol resorption than elimination. To assess this effect for alcoholised e-scooter driving, results of a real-driving fitness study were subanalysed. Methods Sixteen subjects (9 females; 7 males) who completed runs at comparable BACs in the phases of alcohol resorption and elimination were chosen to assess a possible “Mellanby effect”. The data of the subjects was taken from a prior e-scooter study by Zube et al., which included 63 subjects in total. Results In the phase of alcohol resorption, the relative driving performance was approx. 92% of the phase of elimination (p value 0.21). Statistically significant more demerits were allocated to the obstacle “narrowing track” in the phase of resorption than elimination. Subjects also needed significantly more time to pass the obstacles “narrowing track”, “driving in circles counterclockwise” and “thresholds” in the phase of resorption than elimination. Discussion The most relevant obstacle to discriminate between the two different states of alcoholisation was the narrowing track. Insofar, measurements of the standard deviation of the lateral position (SDLP) might also be a sensitive component for the detection of central nervous driving impairment during shorter trips with an e-scooter. Additionally, driving slower during the phase of alcohol resorption seems to be the attempt to compensate alcohol-related deficits. Conclusion The results of the study suggest a slight Mellanby effect in e-scooter drivers.

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“…For example, the time of alcohol ingestion, phase of drunkenness, fatigue and hangover, drinking habits, age, social status, concomi tant ingestion of drugs, concomitant presence of some disease, nutritional status and indivi dual factors have proved to be important additional factors and have been shown to increase the number of erroneous test per formances of alcohol-intoxicated subjects (Bschor, 1951;Alha, 1956;Kurzinger, I960;1966;Griiner et al, 1961;Krauland et al-> 1963;Ducho, 1967;Steigleder, 1968;Milner, 1972;Penttila et al, 1974.…”

Section: Additional Factorsmentioning

confidence: 98%