Studie zu den Modifikationen der mineralisierenden Eigenschaften eines Speichelersatzmittels

Tschoppe, Peter; Kielbassa, Andrej M.; Toll, R.; Meyer-Lückel, Hendrik

doi:10.1055/s-0029-1224107

Cited by 9 publications

(5 citation statements)

References 18 publications

(25 reference statements)

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“…For aqueous solutions, the degree of saturation with respect to apatites [HA, octacalcium phosphate (OCP), dicalcium phosphate dihydrate (DCPD), and calcium fluoride (CaF 2 )] can be calculated, if the pH and the concentrations of certain ions are known [62]. In a previous study [27] that determined the composition of the SN used in the present one, IONPRODUCT, which was developed by Peter Shellis [62], was used. IONPRODUCT is a computer program that calculates the ionic activity of products and the degree of solution saturation with respect to biologically relevant calcium phosphates.…”

Section: Discussionmentioning

confidence: 99%

“…Because patient acceptance of slightly acidic saliva substitutes is higher compared to products with neutral pH values, the current pH values of SN as well as of G might support patient compliance [27,33]. In the present study, an experimental period of seven weeks was selected.…”

Section: Discussionmentioning

confidence: 99%

“…Saliva natura (SN; medac, Germany) was modified by the addition of calcium, phosphates, and fluorides (Table 2), which resulted in a solution with an octacalcium phosphate saturation (S OCP ) of 2.0 at a buffered pH of 5.95 [27,28]. Glandosane (G; cell pharm, Hanover, Germany), which represents a demineralizing saliva substitute, was tested in its pure form (original drug).…”

Section: Methodsmentioning

confidence: 99%

“…The expected mean value of mineral loss was 200 vol% × μm with a standard deviation of 400 vol% × μm. These values were calculated taking into account the ascertained values of previous in vitro studies [27,33]. In detail, those studies gave informations about the required contact time between specimens surface and saliva substitute in vitro , thus these results served as base for determining the specimens in situ contact time storage.…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, enhanced remineralization could be observed after the addition of calcium, phosphates, and fluorides to saliva substitutes. A modified version of Saliva natura (a polysaccharide-based saliva substitute) that is supersaturated with respect to octacalcium phosphate (S OCP = 2) was capable of inducing enamel and dentin remineralization in vitro [27,28]. However, hitherto no clinical study has confirmed the numerous in vitro results showing that saliva substitutes have de- or remineralizing effects on dental hard tissues.…”

Section: Introductionmentioning

confidence: 99%

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Design of a randomized controlled double-blind crossover clinical trial to assess the effects of saliva substitutes on bovine enamel and dentin in situ

Tschoppe¹,

Wolf²,

Eichhorn³

et al. 2011

BMC Oral Health

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BackgroundHyposalivation is caused by various syndromes, diabetes, drugs, inflammation, infection, or radiotherapy of the salivary glands. Patients with hyposalivation often show an increased caries incidence. Moreover, hyposalivation is frequently accompanied by oral discomfort and impaired oral functions, and saliva substitutes are widely used to alleviate oral symptoms. However, preference of saliva substitutes due to taste, handling, and relief of oral symptoms has been discussed controversially. Some of the marketed products have shown demineralizing effects on dental hard tissues in vitro. This demineralizing potential is attributed to the undersaturation with respect to calcium phosphates. Therefore, it is important to modify the mineralizing potential of saliva substitutes to prevent carious lesions. Thus, the aim of the present study was to evaluate the effects of a possible remineralizing saliva substitute (SN; modified Saliva natura) compared to a demineralizing one (G; Glandosane) on mineral parameters of sound bovine dentin and enamel as well as on artificially demineralized enamel specimens in situ. Moreover, oral well-being after use of each saliva substitute was recorded.Methods/DesignUsing a randomized, double-blind, crossover, phase II/III in situ trial, volunteers with hyposalivation utilize removable dentures containing bovine specimens during the experimental period. The volunteers are divided into two groups, and are required to apply both saliva substitutes for seven weeks each. After both test periods, differences in mineral loss and lesion depth between values before and after exposure are evaluated based on microradiographs. The oral well-being of the volunteers before and after therapy is determined using questionnaires. With respect to the microradiographic analysis, equal mineral losses and lesion depths of enamel and dentin specimens during treatment with SN and G, and no differences in patients' experienced oral comfort after SN compared to G usage are expected (H0).DiscussionUp to now, 14 patients have been included in the study, and no reasons for early termination of the trial have been identified. The design seems suitable for determining the effects of saliva substitutes on dental hard tissues in situ, and should provide detailed information on the oral well-being after use of different saliva substitutes in patients with hyposalivation.Trial registrationClinicalTrials.gov ID. NCT01165970

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%