It is a well known fact t h a t in pernicious a n e m i a there are anisocytosis, poikilocytosis and an increased mean red cell diameter. The cause of these changes is generally attributed t o the lack of a specific hemopoietic principle.Changes in the blood picture are also t o be found in a number of cases with disorders of the liver. Thus a relative increase in the mean diameter of the erythrocytes and a n anisocytosis which rises with the increasing mean diameter, are t o be observed in almost every case of acute hepatitis (12).Hence the hematological changes of pernicious anemia and hepatitis offer certain similarities. In addition t o this there is the fact that the liver probably occupies a central position in the pathogenesis of both disorders. It would therefore have seemed reasonable t o suggestas has already been done by several authors (3, 8, 16, 20, 22) that macrocytosis in severe liver damage may be due Danderydsgatan 12, Stockholm.