Studi aktivitas ekstrak etanol dan sediaan gel daun melinjo (Gnetum gnemon L) sebagai antibakteri terhadap Staphylococcus Aureus

Tarigan, Indra Lasmana; Muadifah, Afidatul; Amini, Helda Wika; Astutik, Tri Kurnia

doi:10.22437/chp.v4i2.7631

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…showed that during storage all preparations, both nanoemulsion gel which were stored at room temperature for 12 weeks showed a pH but it was not very significant but the resulting pH value still met the skin pH requirements, namely 4.5-6.5. 22 If the pH of the preparation is too acidic it can cause skin irritation, while a pH that is too alkaline can cause dry and scaly skin. Decrease in pH that is too significant can cause preparation to become watery, which can cause the preparation to become unstable.…”

Section: Discussionmentioning

confidence: 99%

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Sembiring,

Reveny,

Dalimunthe

2023

Int J Basic Clin Pharmacol

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Background: Acne is a chronic inflammatory process in the pilosebaceous glands. The appearance of acne is a process of follicular hyper-keratinization, which causes blockage of the pores so that the hair follicles are blocked by bacteria known as Propionibacterium acnes. Clove flower oil contains eugenol compounds which have the strongest activity against gram-positive and gram-negative bacteria. Methods: In this research, antibacterial activity tests were carried out on clove flower oil with various concentrations and nano-emulsion gel preparations were made with a clove flower oil concentration of 1.5%; 3%; 5.5%, which was then tested for antibacterial activity on the nano-emulsion gel preparations of clove flower oil measured using a caliper and the diameter of the inhibition zone produced was recorded. Results: the results of the organoleptic research showed that the color was yellow, transparent and had a distinctive odor, homogeneity showed that there were no coarse particles, viscosity was still within the required range, pH showed that the pH was still within the required range of 4.5-6.5, particle size test was below 200 nm, cycling test showed that it was stable during storage at hot and cold temperatures for 6 cycles of P. acnes inhibitory clove flower oil nano-emulsion preparation with a concentration of 1.5%; 3%; 5.% respectively have resistance of 11.60 mm, 13.53 mm, 15.76 mm Conclusions: From the results of the research that has been carried out, it is concluded that clove flower oil can be formulated into a nano-emulsion gel preparation, is stable during cycling tests, and has a particle size below 200 nm. Nano-emulsion gel formulations have the greatest antibacterial activity compared to emulsion gel formulations.

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Section: Discussionmentioning

confidence: 99%

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Sembiring,

Reveny,

Dalimunthe

2023

Int J Basic Clin Pharmacol

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“…Pengujian organoleptis dilakukan dengan mengamati bau, warna, dan bentuk dari sediaan gel menggunakan panca indera penglihatan, penciuman dan peraba [11]. partikel-partikel kasar pada permukaan kaca transparan [11].…”

Section: Evaluasi Stabilitas Sediaan Gelunclassified

“…Uji viskositas dilakukan dengan sebanyak 100 gram sediaan gel dimasukkan ke dalam beaker glass 250 ml, lalu viskositas diukur menggunakan Viskometer kemudian digunakan spindle 4 dan kecepatan 6 rpm [11].…”

Section: Bahanunclassified

Repellent Activity Test Of Essential Oil Gel Of Cinnamommum Burmanii Bi Leaves Against Aedes Aegypti Mosquitoes

Bayuadi

Purwati

Panjaitan

2023

IJPR

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Cinnamomum burmanni BI leaf is known to have high eugenol content, eugenol able to resist the bite of Aedes aegypti mosquito as a vector of Dengue Hemorrhagic Fever. Research on test of repellent activity of gel oil Cinnamomum burmanni BI leaf to Aedes aegypti mosquito is done to know its activity as a repellent preparation against Aedes aegypti mosquito. In this research made the gel of essential oil of Cinnamomum burmanni BI leaf with base karbopol 940 made in 3 formula, F1 (7,50%); F2 (15,00%); F3 (30,00%) and use Positive Control repellent supply on the market and contains DEET. The three formulas produce a good gel in terms of physical stability, organoleptic, homogeneity, pH, viscosity, and scattering, but all formulas cause irritation. The test of repellent activity against Aedes aegypti mosquito done for 4 hours with 5 repetitions showed Cinnamomum burmanni BI leaf oil formula F3 (30,00%) had repellent activity against Aedes aegypti mosquito with high protection 94,01% for 4 hours.

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“…Jika P > 0,05, data dianggap berdistribusi teratur tetapi, P < 0,05 maka data tidak berdistribusi normal. Jika data berdistribusi normal, maka selanjutnya dilakukan analisis menggunakan One Way ANOVA, hipotesis diterima jika nilai uji P > 0,05 sedangkan jika P < 0,05 maka hipotesis ditolak (Tarigan et al 2019). kemudian untuk mengetahui besarnya perbedaan antar ke lompok dilanjutkan uji Tukey HSD (Rambe et al 2021).…”

Section: Kesimpulanunclassified

Uji Antidiare Ekstrak Etanol Daun Matoa (Pometia pinnata) Terhadap Mencit Jantan Diinduksi Oleum Ricini

Hasanah,

Saputri,

Siahaan

et al. 2023

jharma

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Matoa leaf is a plant that is used as traditional medicine. Matoa leaves contain tannins, alkaloids, flavonoids, steroids, and glycosideswhich acts as an antidiarrheal. Oleum riciniis a triglyceride that is efficacious as a laxative. The purpose of this study was to prove that matoa leaves can be efficacious as an antidiarrheal. This study used an experimental method, using matoa leaf assay (Pometia pinnata J. R Forst & G. Forst.) with oleum ricini induction. This research includes the collection, processing, phytochemical screening, preparation of suspension of ethanol extract of matoa leaves, and testing the effectiveness antidiarrheal of suspension of ethanolic extract of matoa leaves (Pometia pinnata J.R. Forst& G. Forst.). The results of phytochemical screening on matoa leaf simplicia powder (Pometia pinnata J. R. Forst& G. Forst.) and ethanol extract of matoa leaf (Pometia pinnata J. R. Forst & G. Forst.) which has tannins, alkaloids, saponins, flavonoids, and triterpenoids. The results showed that EEDM at a dose of 300 mg/kg bw had an antidiarrheal effect comparable to EEDM at a dose of 150 mg/kg bw and had a stronger antidiarrheal effect than EEDM 75 mg/kg bw. The results also showed that the EEDM dose of 300 mg/kgbw was not significantly different from that of Loperamide HCl.

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Studi aktivitas ekstrak etanol dan sediaan gel daun melinjo (Gnetum gnemon L) sebagai antibakteri terhadap Staphylococcus Aureus

Cited by 10 publications

References 9 publications

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria

Repellent Activity Test Of Essential Oil Gel Of Cinnamommum Burmanii Bi Leaves Against Aedes Aegypti Mosquitoes

Uji Antidiare Ekstrak Etanol Daun Matoa (Pometia pinnata) Terhadap Mencit Jantan Diinduksi Oleum Ricini

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