Purpose Determine how an interprofessional simulation influences learners' perceptions, role-identification, selfefficacy, and intention to collaborate with other professions on pain issues. Methods This was a quality improvement initiative. An interprofessional education activity was conducted focusing on pain management student learners from medicine, pharmacy, nursing, physical and occupational therapy. Sequential questionnaires were administered pre-and post-participation in two interprofessional education events utilizing a simulated patient case depicted by standardized patients. Results In total, 433 students participated. Across all domains, increased odds of reporting a more favorable response after exposure to each activity was recorded (OR between 1.45 and 9.07). Conclusion The results demonstrate significant positive effects after participation in interprofessional education activities. The large number and variety of student participants, response rates on the questionnaire, and high level of overall positive responses make these results valuable for shaping this activity and may inform other university education initiatives.