The field of cultural studies in Latin America has had a long history and a series of both productive and convoluted developments. Today, its widespread academic commodification and institutionalization in graduate programs deter incisive, critical, and politically daring works that question the limits of the field. Even when there has never been just one way of understanding and practicing cultural studies—its internal differences are mainly due to its local geo-cultural and sociohistoric contextualization—cultural studies in Latin America cannot be understood without the transnational circulation of knowledge, hegemonized by Anglo-Saxon—British as well as American—influences and overdeterminations. Four specific and abridged transformations help sieve through this complex history intricately enmeshed in specific sociopolitical, economic, and cultural processes vis-à-vis epistemic and hermeneutic theoretical projects. These moments are unraveled from the specific articulations built from local traditions of critical thinking mixed with exogenous theories and discourses from the time when self-reflexive postmodern irony and globalization began materializing in a qualitative higher degree around the globe to its critically silent acquiescence.