Stryspinolactone, an unusual monoterpene lactone from Strychnos spinosa

Adesogan, E. K.; Morah, Francis N.

doi:10.1016/0031-9422(81)83101-9

Cited by 13 publications

(23 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, using NMR and mass spectrometry, phytosterols have also been unveiled in fruits: clerosterol, βsitosterol, stigmastanol, stigmasterol and saringosterol (Morah, 1993;Hoet et al, 2007 ;Ibrahim et al, 2014; Figures 1 and 2). Finally, a saponin (Triploside A) and a lignan (Lirioresinol B) were also identified in the branches (Adesogan and Morah, 1981;Itoh et al, 2005). The main compounds unveiled in S. spinosa are terpenes (more than 60%), followed by sterols, fatty acids and flavonoids.…”

Section: Phytochemistrymentioning

confidence: 98%

“…This is the only mention of antidiabetic properties of S. spinosa in Sub-Saharan Africa. On the contrary, the treatment of snakebite with the plant, was mentioned by numerous studies from across the region: in Nigeria, South Africa and Mali (Adesogan and Morah, 1981;Lockett et al, 2000;Molander et al, 2014;Lawal et al, 2019). Finally, various ethnomedicinal uses have also been retained: haemorrhoids, conjunctivitis, eye diseases, diarrhoea, toothache, stomach-ache, hernia, miscarriage prevention, speed of the delivery process, milk production of the new mom, unblocking of respiratory difficulties, etc.…”

Section: Usages In Ethnomedicinementioning

confidence: 99%

“…However, some terpenoid alkaloids have been deciphered in leaves and stems barks of this plant using spectroscopic means namely nuclear magnetic resonance (NMR) and mass spectrometry combined with extraction and various liquid chromatographic techniques to isolate pure compounds: akagerine, 10-hydroxy-akagerine, kribine, 11-methoxydiaboline (Ohiri et al, 1983). Using the same means, other types of terpenes have also been found in the fruits and leaves: stryspinolactone (monoterpen secoiridoid), kingiside aglycone, α-amyrin, β-amyrin, uvaol, lupeol, erythrodiol, ursolic acid (pentacyclic triterpens) (Adesogan and Morah, 1981;Msonthi et al, 1985;Morah, 1993;Hoet et al, 2007; Figures 1 and 2). Concerning secoiridoids, NMR and mass spectrometry led to detect in the plant branches, three new secoiridoid glucosides namely stryspinoside, strychoside A and strychoside B alongside other compounds such as: loganin, secologanin, sweroside, secoxyloganin, secologanin, dimethyl acetal, secologanoside, secologanoside 7-methyl ester, secologanoside dimethyl ester, secologanic acid, vogeloside, 14 epi-vogeloside, 14 (5S)-5-carboxystrictosidine, astragalin and nicotiflorin (Itoh et al, 2005, Figures 1 and 2).…”

Section: Phytochemistrymentioning

confidence: 99%

“…The fruits of the plant are mainly consumed by people (Akpavi et al, 2011), and are also transformed to make jam, jelly and processed products (Ngadze et al, 2017), whereas the leaves are turned into vegetable sauce (Guissou et al, 2015). The diverse uses of this plant are linked to its phytochemical compounds such as akagerine, kribine, 11methoxy-diaboline, stryspinolactone, stryspinoside, strychoside A and B, α-amyrin, β-amyrin, uvaol, lupeol, erythrodiol, ursolic acid (Adesogan and Morah, 1981;Ohiri et al, 1983;Msonthi et al, 1985;Morah, 1993;Hoet et al, 2007); and linalool, geraniol, terpineol, nerolidol, palmitic acid and isopropyl myristate, which have also been detected in the essential oils of its leaves (Hoet et al, 2006). Various biological properties have been demonstrated for S. spinosa and its components (Hoet et al, 2007;Bero et al, 2009;Maregesi et al, 2016;Nciki et al, 2016;Mbunde et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Strychnos Spinosa Lam: Comprehensive Review on Its Medicinal and Nutritional Uses

Tittikpina¹,

Atakpama²,

Hoekou³

et al. 2020

AJTCAM

View full text Add to dashboard Cite

Background: Most of the people living in developing countries rely on local remedies from traditional medicines to take care of their healthcare needs. In recent years, the use of medicinal plants increased considerably. Consequently, studies on medicinal plants are necessary to produce more effective drugs with fewer side-effects. This work aims to compile the dispersal data on Strychnos spinosa Lam., a medicinal plant with great therapeutic potential in traditional medicine, on its ethnobotanical uses, chemical compounds, as well as its pharmacological and nutritional effects. Material and Methods: To achieve the aforementioned aim, electronic databases such as Pubmed, Science Direct, Google scholar, Scopus and SciFinder were scanned. Results: Literature survey revealed that S. spinosa is used in the treatment of microbial infections, malaria, trypanosomiasis, intestinal worms, tuberculosis, infertility, gastrointestinal disorders, snake bite, hypertension, and diabetes mellitus among other ailments. The plant is also used as food material. S. spinosa contains many chemical compounds, such as alkaloids, terpenes, sterols, fatty acids, flavonoids, saponin, and others. The fruits are a source of important nutrients such as carbohydrates, sugars, proteins, vitamins and fibres. Experimental studies have shown numerous pharmacological properties, including antimicrobial, antiplasmodial, anti-trypanosomal, anti-leishmanial, anti-nematicidal, anti-inflammatory, anti-oxidant, antidiabetic and other activities. Conclusion: This review article provides comprehensive information on S. spinosa and its various extracts. Due to the promising effects of the plant extracts on various diseases and its nutritional values, there is a need for toxicity studies and clinical trials to assess the effects of its identified bioactive compounds.

show abstract

Section: Phytochemistrymentioning

confidence: 98%

Section: Usages In Ethnomedicinementioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Strychnos Spinosa Lam: Comprehensive Review on Its Medicinal and Nutritional Uses

Tittikpina¹,

Atakpama²,

Hoekou³

et al. 2020

AJTCAM

View full text Add to dashboard Cite

show abstract

“…The antioxidant activity of the fruit extract of the same species was determined [ 10 ]. Several secondary metabolites including triterpenoids, sterols and essential oils [ 6 , 7 ] secoiridoids [ 11 , 12 ], alkaloids [ 13 ], and monoterpenes [ 14 ] have been indicated or isolated from Strychnos spinosa .…”

Section: Introductionmentioning

confidence: 99%

Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities

Isa

Awouafack

Dzoyem

et al. 2014

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundStrychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study is designed to determine the antimicrobial, antioxidant and cytotoxic activities of extracts and fractions from leaves of S. spinosa.MethodsExtracts were obtained by maceration with acetone, methanol and dichloromethane/methanol (1/1) while fractions were prepared by liquid-liquid fractionation of the acetone extract. A broth serial microdilution method with tetrazolium violet as growth indicator was used to determine the minimum inhibitory concentration (MIC) against fungi, Gram-positive and Gram-negative bacteria. The antioxidant activity was determined using free-radical-scavenging assays, and the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide reduction assay was used to determine cytotoxicity.ResultsFour extracts and five fractions had good to weak antimicrobial activity with MICs ranging from 0.04 to >1.25 mg/ml against both fungi and bacteria. The chloroform and ethyl acetate fractions had an MIC of 0.08 mg/ml against Aspergillus fumigatus. The n-butanol fraction had an MIC of 0.04 mg/ml against Cryptococcus neoformans. The hexane and chloroform fractions had an MIC of 0.08 mg/ml against Staphylococcus aureus. The antioxidant activities were much lower than that of the positive controls. Except for the alkaloid extract, all the extracts and fractions had free-radical-scavenging activity (IC50 ranging from 33.66 to 314.30 μg/ml). The cytotoxicity on Vero cells was reasonable to low with LC50 values ranging between 30.56 and 689.39 μg/ml.ConclusionThe acetone extract and the chloroform fraction had the highest antibacterial activity. By solvent-solvent fractionation it was possible to increase the activity against A. fumigatus and to decrease the cytotoxicity leading to a potentially useful product to protect animals against aspergillosis. Our results therefore support the use of S. spinosa leaves in traditional medicine to treat infectious diseases.

show abstract

Miscellaneous Monoterpenes

Atta-ur-Rahman

Ahmad

1992

13c-NMR of Natural Products

View full text Add to dashboard Cite

Stryspinolactone, an unusual monoterpene lactone from Strychnos spinosa

Cited by 13 publications

References 2 publications

Strychnos Spinosa Lam: Comprehensive Review on Its Medicinal and Nutritional Uses

Strychnos Spinosa Lam: Comprehensive Review on Its Medicinal and Nutritional Uses

Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities

Miscellaneous Monoterpenes

Contact Info

Product

Resources

About