Struma Lymphomatosa: Primary Thyroid Failure With Compensatory Thyroid Enlargement*

Kinetics of Thyroxine and Triiodothyronine in a Case of Thyroxine-binding Globulin Deficiency with Hypothyroidism

“…But his younger sister had both rheumatoid arthiritis and goiter though chronic thyroiditis was not confirmed. Recently, chronic thyroiditis and primary hypothyroidism are said to be clinical variants of the same disease (Skillern et al 1956). It occurs often in the same family (Dunning 1959) and it is frequently complicated with rheumatic diseases (Buchanan et al 1961).…”

A 50-year Revisit of the Initiation and Associations of Hashimoto’s Disease: Might Findings Conform to a Concept of Multifactorial Physiopathologic Transitions?

“…One may hypothesize that the greater the extent to which HD may be initiated by a primary thyroid dysfunction 4,5,8,9 , the less frequently might associated autoimmune disorders be expected. Assuming HD is caused primarily by an immune dysregulation 6,7,28 , the more frequently other associated autoimmune disorders might be expected.…”

“…The review 1 rekindled long-past memories, and this commentary offers a personal historical perspective on some complex research questions and challenges persisting in HD and its associated conditions. Such issues had been posed some 2 generations ago 2,3,4,5,6,7,8,9,10 (Table 1), but have not yet been adequately resolved.…”

“…A primary question remains: is HD a primary thyroid dysfunction 5 and does epithelial basement membrane injury 4,9 precede the initiation of autoimmunity? The more popular alternative question is, does thyroid autoimmunity primarily cause chronic thyroiditis 6,7,11 ?…”

A Review of “Auto-Immunization” in Hashimoto–s Disease

“…Four patients with Hashimoto's disease were found to have significantly elevated values for serum gamma globulin. Others have since noted this electrophoretic change, and also that results of the "colloidal gold," "thymol turbidity" and "cephalin flocculation" tests frequently were positive in the presence of this disease (17)(18)(19)(20).…”