Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung N<sup>α</sup>‐substituierter Histamine

Hepp, M.; Schunack, Walter

doi:10.1002/ardp.19803130905

Cited by 10 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For details concerning the three histaminergic compounds N",5-dimethylhistamine-dichloride, 5-ethyl-N"-methyl-histamine-dihydrochloride and N'~,N"-dimethyl-histamine-dihydrochloride see [5] and [6]. For details concerning the three histaminergic compounds N",5-dimethylhistamine-dichloride, 5-ethyl-N"-methyl-histamine-dihydrochloride and N'~,N"-dimethyl-histamine-dihydrochloride see [5] and [6].…”

Section: Methodsmentioning

confidence: 99%

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

et al. 1985

Self Cite

View full text Add to dashboard Cite

First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Na,5-dimethylhistamine (HC1)2, 5-ethyl-Na-methyl-histamine (HC1)2, Na,Na-dimethyl-histamine (HC1)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine. Dose-response curves for the histamine derivatives were 1.7-2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater for Na,5-dimethyl-histamine (HC1)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

et al. 1985

Self Cite

View full text Add to dashboard Cite

show abstract

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 22. Mitt. Absolute Konfiguration und histaminartige Wirkung der enantiomeren α, N^α‐Dimethylhistamine

Gerhard

Schunack

1980

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: STRUCTURE‐ACTIVITY RELATIONS OF HISTAMINE ANALOGS. XXI. SYNTHESIS AND EFFECT OF Nα‐SUBSTITUTED HISTAMINES

Hepp¹,

Schunack²

1981

Chemischer Informationsdienst

View full text Add to dashboard Cite

show abstract

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung N^α‐substituierter Histamine

Abstract: Es wurden Nα‐substituierte Histamine dargestellt und auf ihre agonistische Wirkung an Histamin H1‐ und H2‐Rezeptoren untersucht.

Cited by 10 publications

References 16 publications

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 22. Mitt. Absolute Konfiguration und histaminartige Wirkung der enantiomeren α, N^α‐Dimethylhistamine

ChemInform Abstract: STRUCTURE‐ACTIVITY RELATIONS OF HISTAMINE ANALOGS. XXI. SYNTHESIS AND EFFECT OF Nα‐SUBSTITUTED HISTAMINES

Contact Info

Product

Resources

About

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung Nα‐substituierter Histamine

Abstract: Es wurden Nα‐substituierte Histamine dargestellt und auf ihre agonistische Wirkung an Histamin H1‐ und H2‐Rezeptoren untersucht.

Cited by 10 publications

References 16 publications

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 22. Mitt. Absolute Konfiguration und histaminartige Wirkung der enantiomeren α, Nα‐Dimethylhistamine

ChemInform Abstract: STRUCTURE‐ACTIVITY RELATIONS OF HISTAMINE ANALOGS. XXI. SYNTHESIS AND EFFECT OF Nα‐SUBSTITUTED HISTAMINES

Contact Info

Product

Resources

About

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung N^α‐substituierter Histamine

Struktur‐Wirkungs‐Beziehungen bei Histaminanaloga, 22. Mitt. Absolute Konfiguration und histaminartige Wirkung der enantiomeren α, N^α‐Dimethylhistamine