Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid

Abstract

In recent years, polymeric materials have been used in a wide range of applications in a variety of fields. In particular, in the field of bioengineering, the use of natural biomaterials offers a possible new avenue for the development of products with better biocompatibility, biodegradability, and non-toxicity. This paper reviews the structural and physicochemical properties of alginate and hyaluronic acid, as well as the applications of the modified cross-linked derivatives in tissue engineering and drug delivery. This paper summarizes the application of alginate and hyaluronic acid in bone tissue engineering, wound dressings, and drug carriers. We provide some ideas on how to replace or combine alginate-based composites with hyaluronic-acid-based composites in tissue engineering and drug delivery to achieve better eco-economic value.

Resorbable conductive materials for optimally interfacing medical devices with the living

“…HA is fully resorbable, with a degradation rate of a few hours to days (according to the body location) when not cross-linked. Other polysaccharides of interest for medical applications are chitosan which presents mucoadhesive properties ( Dash et al, 2011 ), cellulosics ( Aghazadeh et al, 2022 ), and alginate ( Zhang et al, 2023 ). Though they display high biocompatibility and are degradable, only a few of their derivatives, such as oxidized cellulose and oxidized alginate, appear resorbable.…”

Potentiating Gilteritinib Efficacy Using Nanocomplexation with a Hyaluronic Acid–Epigallocatechin Gallate Conjugate

“…In this perspective, it is desirable to develop advanced nanoparticle formulations capable of enhancing the anti-leukemic activity of GLT for more effective AML treatment. Hyaluronic acid (HA) is a linear and non-sulfated carbohydrate polymer that consists of disaccharide repeating units of N-acetyl-D -glucosamine and D -glucuronic acid [6]. Owing to its unique viscoelastic, non-immunogenic, and biodegradable properties, HA has been widely explored for diverse biomedical and pharmaceutical applications, such as viscosupplementation, drug delivery, soft tissue augmentation, and cartilage tissue engineering [7][8][9].…”

Meso-2,3-dimercaptosuccinic Acid–Based Macromers for pH-Sensitive Degradable Hydrogels

“…In particular, pH-responsive hydrogels have become very popular and are highly studied, especially in the biomedical field, since the pH of inflamed or cancerous tissue is slightly different from that of healthy tissue. , An important subgroup of pH-responsive hydrogels is composed of anionic ones. Their tunable pH-dependent swelling behaviors make them excellent materials for use in drug delivery systems, while their heavy metal complexing ability makes them important for metal chelation studies. − Carboxylic acid containing hydrogels can be prepared from natural polymers such as chitosan, alginate, and hyaluronic acid or from synthetic polymers such as poly­(acrylic acid) or macromers with various methods. , …”

“…13−15 Carboxylic acid containing hydrogels can be prepared from natural polymers such as chitosan, alginate, and hyaluronic acid or from synthetic polymers such as poly(acrylic acid) or macromers with various methods. 16,17 Since hydrogels generally do not have sufficient mechanical strength for desired biomedical applications, producing hydrogels with high mechanical performance such as nanocomposite hydrogels and double-network hydrogels has become a subject of much research recently. 18−20 In the hybrid double-network hydrogels, chemical cross-linking can be achieved by covalent bonds, while physical cross-linking can be achieved by various methods such as ionic interaction, hydrogen bonds, and hydrophobic association.…”