Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review

He, Xirui; Fang, Jugao; Ruan, Yinlan; Wang, Xiaoxiao; Sun, Yin; Wu, Na; Zhao, Zhengyan; Chang, Yu Sun; Ning, Ning; Guo, Hao; Huang, Libei

doi:10.1016/j.foodchem.2017.11.084

Cited by 150 publications

(99 citation statements)

References 60 publications

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“…Mulberry leaf (Morus alba L.) is one of the Chinese traditional edibile plants, which is extensively consumed in various forms such as tea, biscuits, beverage in our daily life [26,27]. Mulberry leaf is rich in active compounds including alkaloids, flavonoids, polysaccharides, and phenolic compounds, which possesses multiple pharmacological activities containing anti-thrombotic, anti-diabetic, anti-hypertensive, anti-bacterial, anti-inflammatory, and anti-aging [28,29]. Indeed, recent studies demonstrated that its leaves are used to treat type 2 diabetes, cardiovascular disorders, urinary system, anti-tumor, and so on [30].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the AMPK/Nrf2 Signaling Pathway in A549 Cells

et al. 2020

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Neochlorogenic acid (nCGA) is a phenolic compound isolated from mulberry leaf (Morus alba L.), which possesses multiple pharmacological activities containing antioxidant and anti-inflammatory effects. However, the role of nCGA in the treatment of acute pneumonia and the underlying molecular mechanism are still unclear. Hence, the aim of study is to investigate the anti-inflammatory properties of nCGA on LPS-stimulated inflammation in A549 cells. In the present study, results reported that nCGA without cytotoxicity significantly reduced the production of TNF-α, IL-6, and NO, and further suppressed the proteins of iNOS, COX2, TNF-α, IL-6 expression. Furthermore, nCGA also inhibited NF-κB activation and blocked MAPKs signaling pathway phosphorylation. In addition, we found nCGA significantly increased the expression of HO-1 via activating the AMPK/Nrf2 signaling pathway to attenuate the inflammatory response, whereas this protective effect of nCGA was reversed by pre-treatment with compound C (C.C, an AMPK inhibitor). Therefore, all these results indicated that nCGA might act as a natural anti-inflammatory agent for the treatment of acute pneumonia.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the AMPK/Nrf2 Signaling Pathway in A549 Cells

et al. 2020

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“…Mulberry leaves silage probably contains polyphenols and polysaccharides that could exert similar effects, as polyphenols and polysaccharides can inhibit in ammatory processes by improving serum IFN-γ concentration or affecting microbiota [40,41]. In addition, cumulative evidences indicate that mulberry leaf polysaccharides have immunomodulating activity, which has been assessed on many different kind cells and macrophage-dependent immune system responses [42]. Here, we show, to our knowledge for the rst time, the ruminal Bi dobacterium and Lactobacillus genera were increased by feeding mulberry leaf silage in sheep which were also positively correlated with the serum IFN-γ concentration in the current study.…”

Section: Discussionmentioning

confidence: 99%

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Wang¹,

Luo²

2020

Preprint

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Background: Rumen is a natural fermentation system and the microorganisms inside can effectively utilize plant bioresource and interact with host metabolism. Here, analysis of rumen microbiome, together with animal performance and serum metabolism in a lamb model were performed to identify the potential use of mulberry leaf silage (MS) to replace alfalfa silage (AS) as a new functional feed resource and to mining the novel specific mulberry leaf associated rumen bacteria interact with host metabolism. Results: The lambs fed with MS diet showed improved antioxidant capacity and immune function compared to those fed AS diet. The MS diet significantly altered rumen microbiota α- and β-diversity and taxonomic composition. Microbial analysis revealed that Bifidobacterium, Lactobacillus and Schwartzia were enhanced, and Ruminococcaceae UCG-010 and Lachnospiraceae_XPB1014_group were down-regulated in the rumen of MS group. A strong association was also found between these rumen microbial taxa and host antioxidant capacity and immunomodulatory. Conclusion: These findings indicated that mulberry leaf silage can be a high-quality feed source or bioactive pharmaceutical that is responsible for ruminants health benefits by modifying the rumen microbial community with potentially enhanced probiotics and inhibited biohydrogenation and methane emission.

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“…The monosaccharide of mulberry fruits is comprising of glucose, arabinose, galacturonic acid, and galactose (22). While the immense majority of the polysaccharide reported from mulberry fruits ( Table 2) are acid heteropolysaccharides, which are the primary source of α, β-glycosidic linked glucans, these mulberry fruit polysaccharides (MFPs) exert remarkable medicinal effects on human health (23).…”

Section: Nutrientsmentioning

confidence: 99%

“…(32,35,36). Out of the 20 components, the chief anthocyanin isolated from mulberry fruit is Cyanidin 3-O-glucoside (301.75 mg/ g of mulberry anthocyanin extract), which exerts antidiabetic and antitumor activity (23,37).…”

Section: Polyphenolsmentioning

confidence: 99%

Nutraceutical and Medicinal Property of Mulberry Fruits: A Review on Its Pharmacological Potential

Mandal¹

2020

Preprint

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Mulberry (Morus) cultivated worldwide in diverse agro-ecological conditions recognized as the fodder of silkworms (Bombyx mori). In India, ranging from high altitude Himalayan region to coastal region, the farmers generally cultivate these four species of mulberry (Morus alba, M. indica, M. serrata, and M. laevigata). Mulberry fruit is used in traditional medicine for several years in China and also consumed as food material in different countries of Asia and Africa.Mulberry fruit, along with high nutritious value, contains many bioactive phytochemicals that are of health benefits and can fight against many diseases. Many researchers attracted to this property of mulberry fruit, and they isolated bioactive polysaccharides, anthocyanins, flavonols, flavonols, phenolic acids, alkaloids, and melatonins. These compounds have antioxidant property and due to this, either in synergistically or in the pure form, these components have direct or indirect curative activity on diabetes, inflammation, tumor, hepatic diseases, immunomodulation, hyperlipidemia, neural damage, and chronic diseases. This tremendous bioactivity of mulberry fruit extract may open up a new dimension in the food and medicine industry. The present review provides recent findings of the phytochemical foundation and their bioactivities, which may encourage many researchers to explore the molecular mechanism of the biological activities which can be used for human welfare.

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Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review

Cited by 150 publications

References 60 publications

Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the AMPK/Nrf2 Signaling Pathway in A549 Cells

Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the AMPK/Nrf2 Signaling Pathway in A549 Cells

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Nutraceutical and Medicinal Property of Mulberry Fruits: A Review on Its Pharmacological Potential

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