Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonia lactiflora

Abstract

Fractionation of an aqueous extract of the air-dried roots of a traditional Chinese medicinal plant, Paeonia lactiflora, yielded the new monoterpenoid glycosides 1-10. Their structures were assigned via spectroscopic techniques, and the absolute configurations of 1, 4-6, and 8 were verified via chemical methods, specific rotation, and electronic circular dichroism data. Compounds 1-4 are rare compared to the reported cage-like paeoniflorin derivatives; that is, they comprised two monoterpenoidal moieties. In the in vitro assay, compounds 5, 8, and 9 showed weak inhibitions against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC values of 64.8, 60.1, and 97.5 μM, respectively.

The bioactive compounds and cellular antioxidant activity of Herbaceous peony (Paeonia lactiflora Pall) seed oil from China

“…Phytosterols also attract tremendous attentions mainly due to their important roles in reducing cardiovascular issues and blood low density lipoprotein‐cholesterol, and the reactive oxygen species production and lipid accumulation depended on the types of phytosterols in oils (Li et al., 2018; Shahzad et al., 2017). The content of phytosterols of HP seed oil was first reported in the present study, with the β‐sitosterol, Δ5‐avenasterol, and 24‐methylenecycloartanol being the major types.…”

“…To effectively and better use HP seeds, it is very important to find out their character. To the best of our knowledge, numerous studies have mainly focused on the constituents and biological properties of the root of HP (Leem et al., 2004; Li et al., 2018; Zhu et al., 2015), thus ignoring the bioactive compounds of the HP seed. This topic has only been studied by few studies, leading to the scarce literature about the bioactive compounds of oil extracted from different varieties of HP seed.…”

Illuminating the biosynthesis pathway genes involved in bioactive specific monoterpene glycosides in Paeonia veitchii Lynch by a combination of sequencing platforms

“…Previous phytochemical studies of Paeonia revealed that the active compounds in its roots are primarily monoterpene derivatives with a "cage-like" skeleton, including paeoniflorin, albiflorin, oxypaeoniflorin, benzoylpaeoniflorin, oxybenzoylpaeoniflorin, lactiflorin, galloylpaeoniflorin, and paeonin [4][5][6]. Most of these monoterpene derivatives are monoterpene glycosides (PMGs), especially paeoniflorin [7][8][9].…”

Screening of Biomarkers and Quality Control of Shaoyao Gancao Decoction Using UPLC-MS/MS Combined with Network Pharmacology and Molecular Docking Technology

“…It uses Paeonia lactifora and licorice to nourish yin and blood and to pass through the meridians to treat blood defciency and body pain, including abdominal pain due to qi and blood defciency [2][3][4][5]. Chemical composition studies show that SGD mainly contains favonoids, triterpenoid saponins, monoterpenoid glycosides, phenolic acids, tannins, and some other compounds [6][7][8][9][10][11]. Modern pharmacological studies show that SGD has the functions of relieving spasmolysis and analgesia, protecting the liver, antiinfammatory, relieving cough and asthma, anti-allergy, and immune regulation, etc.…”