Structured triglycerides containing medium-chain fatty acids and linoleic acid differently influence clearance rate in serum of triglycerides in rats

Kishi, Taiji; Carvajal, Octavio; Tomoyori, Hiroko; Ikeda, Ikuo; Sugano, Michihiro; Imaizumi, Kazunori

doi:10.1016/s0271-5317(02)00441-4

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Ash content was determined by the direct ash method (AOAC 942.05). α -Tocopherol 13 and β -carotene 14 contents were measured by high-performance liquid chromatography (HPLC). The column for α -tocopherol was packed with Zorbax SIL (5 μ m, 4.6 × 250 mm; Agilent Technologies, Tokyo, Japan) and the column for β -carotene was packed with Inertsil ODS-3 (5 μ m, 4.6 × 250 mm; GL Sciences Inc, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Sato

Ueda

Nagata

et al. 2011

Exp Biol Med (Maywood)

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Kakrol (Momordica dioica Roxb.) is a cucurbitaceous vegetable native to India and Bangladesh. Bitter gourd (Momordica charantia Linn.), a species related to kakrol, has been shown to have pharmacological properties including antidiabetic and antisteatotic effects. In this study, we investigated the effect of dietary kakrol on lipid metabolism in rats. Sprague-Dawley rats were fed AIN-76 formula diets containing 3% freeze-dried powders of whole kakrol or bitter gourd for two weeks. Results showed significantly lowered liver cholesterol and triacylglycerol levels in rats fed on both diets. Fecal lipid excretion increased in rats fed the kakrol diet, and lymphatic transport of triacylglycerol and phospholipids decreased in rats fed the kakrol diet after permanent lymph cannulation. Furthermore, n-butanol extract from kakrol caused a significant concentration-dependent decrease in the pancreatic lipase activity in vitro. These results indicate that the mechanisms of action on lipid metabolism in kakrol and bitter gourd are different and that dietary kakrol reduces liver lipids by inhibiting lipid absorption.

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Section: Methodsmentioning

confidence: 99%

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Sato

Ueda

Nagata

et al. 2011

Exp Biol Med (Maywood)

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“…Previous researches have proven that MLCTs could be used as the cooking oil, 5 as well as to accelerate the lipid metabolism, thus decreasing blood lipid levels and hepatic and body fat accumulation. 6,12 Rapeseed oil (RO, one kind of LCTs) is a commonly used edible oil in China. Although the FDA claims that RO containing high oleic acid can reduce the risk of coronary heart disease, RO-induced obesity has been proven by many researches.…”

Section: ■ Introductionmentioning

confidence: 99%

Consumption of Interesterified Medium- and Long-Chain Triacylglycerols Improves Lipid Metabolism and Reduces Inflammation in High-Fat Diet-Induced Obese Rats

Chen

Zhu

et al. 2020

J. Agric. Food Chem.

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Medium- and long-chain triacylglycerols (MLCTs) were synthesized from rapeseed oil (RO), one kind of commonly used edible long-chain triacylglycerols (TGs), and then delivered to high-fat diet (HFD)-induced obese rats. Compared with RO, MLCT consumption exhibited more potent effects on reducing body and tissue weight gains, plasma TG, and total cholesterol (TC) levels and on improving hepatic TG, TC, fatty acid synthase, acetyl-CoA carboxylase, and lipoprteinlipase contents. Meanwhile, lower amounts of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1, and endotoxin in plasma, lower levels of interleukin-6 and TNF-α, and higher levels of interleukin-10 in both livers and white adipose tissues were detected in MLCT-fed rats. MLCT intake also remarkably suppressed the size of adipocytes and the number of macrophages. In conclusion, our study suggested that the interesterified MLCT was more efficacious in improving the lipid metabolism and inflammation in HFD-induced obese rats than RO.

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“…The linking of a second fatty acid, which may be similar or different from the existing fatty acid, gives rise to a diacylglyceride. If all three hydroxyl groups of glycerol are linked by fatty acids, then this will be a triacylglyceride [33]. Monoacylglycerides, by having free hydroxyl groups (two) are relatively polar and therefore partially soluble in water.…”

Section: Mono- Di-and Triacylglyceridesmentioning

confidence: 99%

Overview About Lipid Structure

Valenzuela¹,

Valenzuela²

2013

Lipid Metabolism

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Structured triglycerides containing medium-chain fatty acids and linoleic acid differently influence clearance rate in serum of triglycerides in rats

Cited by 6 publications

References 19 publications

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Consumption of Interesterified Medium- and Long-Chain Triacylglycerols Improves Lipid Metabolism and Reduces Inflammation in High-Fat Diet-Induced Obese Rats

Overview About Lipid Structure

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