Structure, regulation, and host interaction of outer membrane protein U (OmpU) of Vibrio species

Ganie, Hilal A.; Choudhary, Aaina; Baranwal, Somesh

doi:10.1016/j.micpath.2021.105267

Cited by 14 publications

(2 citation statements)

References 53 publications

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“…It has a four-domain structure, and three of them are involved in the colonization process (Wong et al, 2012 ). Other adhesion factors such as OmpU and MAM7 are also identified in Vibrio species (including non-cholerae ones) and their role depends on the context of the pathogenic process (Liu et al, 2018 ; Crisan and Hammer, 2020 ; Ganie et al, 2022 ). The MAM7, T3SS, and T6SS are the main factors associated with V. cholerae, V. parahaemolyticus , and Vibrio alginolyticus , and T3SS has a little correlation with V. vulnificus ( Table 1 ).…”

Section: Pathogenic Mechanism Of Common Pathogenic Vibrio ...mentioning

confidence: 99%

Effects of intestinal microbiota on physiological metabolism and pathogenicity of Vibrio

Sun

Zhu

et al. 2022

Front. Microbiol.

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Vibrio species are disseminated broadly in the marine environment. Some of them can cause severe gastroenteritis by contaminating seafood and drinking water, such as Vibrio parahaemolyticus, Vibrio cholerae, and Vibrio vulnificus. However, their pathogenic mechanism still needs to be revealed to prevent and reduce morbidity. This review comprehensively introduces and discusses the common pathogenic process of Vibrio including adhesion, cell colonization and proliferation, and resistance to host immunity. Vibrio usually produces pathogenic factors including hemolysin, type-III secretion system, and adhesion proteins. Quorum sensing, a cell molecular communication system between the bacterial cells, plays an important role in Vibrio intestinal invasion and colonization. The human immune system can limit the virulence of Vibrio or even kill the bacteria through different responses. The intestinal microbiota is a key component of the immune system, but information on its effects on physiological metabolism and pathogenicity of Vibrio is seldom available. In this review, the effects of intestinal microorganisms and their metabolites on the invasion and colonization of common pathogenic Vibrio and VBNC status cells are discussed, which is conducive to finding the next-generation prebiotics. The strategy of dietary intervention is discussed for food safety control. Finally, future perspectives are proposed to prevent Vibrio infection in aquaculture.

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Section: Pathogenic Mechanism Of Common Pathogenic Vibrio ...mentioning

confidence: 99%

Effects of intestinal microbiota on physiological metabolism and pathogenicity of Vibrio

Sun

Zhu

et al. 2022

Front. Microbiol.

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“…The binding of V. cholerae by GbpA led to increased mucus production, which drew more bacteria for better colonization of the host intestinal surface (Rothenbacher and Zhu, 2014 ). VCC was a membrane-damaging protein toxin with potent cytolytic/cytotoxic activity against a wide range of eukaryotic cells (Kathuria and Chattopadhyay, 2018 ), while OmpU was a key adhesion protein and an important virulence factor for the successful colonization of Vibrio species into the host (Ganie et al, 2021 ). Therefore, the identification of virulence determinants in non-O1/O139 V. cholerae isolates is imperative to ensure food safety systems and human health.…”

Section: Introductionmentioning

confidence: 99%

Diverse Aquatic Animal Matrices Play a Key Role in Survival and Potential Virulence of Non-O1/O139 Vibrio cholerae Isolates

et al. 2022

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Vibrio cholerae can cause pandemic cholera in humans. The waterborne bacterium is frequently isolated from aquatic products worldwide. However, current literature on the impact of aquatic product matrices on the survival and pathogenicity of cholerae is rare. In this study, the growth of eleven non-O1/0O139 V. cholerae isolates recovered from eight species of commonly consumed fish and shellfish was for the first time determined in the eight aquatic animal matrices, most of which highly increased the bacterial biomass when compared with routine trypsin soybean broth (TSB) medium. Secretomes of the V. cholerae isolates (draft genome size: 3,852,021–4,144,013 bp) were determined using two-dimensional gel electrophoresis (2DE-GE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques. Comparative secretomic analyses revealed 74 differential extracellular proteins, including several virulence- and resistance-associated proteins secreted by the V. cholerae isolates when grown in the eight matrices. Meanwhile, a total of 8,119 intracellular proteins were identified, including 83 virulence- and 8 resistance-associated proteins, of which 61 virulence-associated proteins were absent from proteomes of these isolates when grown in the TSB medium. Additionally, comparative genomic and proteomic analyses also revealed several strain-specific proteins with unknown functions in the V. cholerae isolates. Taken, the results in this study demonstrate that distinct secretomes and proteomes induced by the aquatic animal matrices facilitate V. cholerae resistance in the edible aquatic animals and enhance the pathogenicity of the leading waterborne pathogen worldwide.

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Integrated toxicology, metabolomics, and transcriptomics analyses reveal the biodegradation and adaptation mechanisms to BDE-47 in Pseudomonas plecoglossicida

Qi¹,

Zhu²,

Yuan³

et al. 2023

Chemical Engineering Journal

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Structure, regulation, and host interaction of outer membrane protein U (OmpU) of Vibrio species

Cited by 14 publications

References 53 publications

Effects of intestinal microbiota on physiological metabolism and pathogenicity of Vibrio

Effects of intestinal microbiota on physiological metabolism and pathogenicity of Vibrio

Diverse Aquatic Animal Matrices Play a Key Role in Survival and Potential Virulence of Non-O1/O139 Vibrio cholerae Isolates

Integrated toxicology, metabolomics, and transcriptomics analyses reveal the biodegradation and adaptation mechanisms to BDE-47 in Pseudomonas plecoglossicida

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