Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Kazemzadeh, Parya; Sayadi, Khalil; Toolabi, Ali; Sayadi, Jalil; Zeraati, Malihe; Chauhan, Narendra Pal Singh; Sargazi, Ghasem

doi:10.3389/fchem.2022.823785

Cited by 34 publications

(27 citation statements)

References 122 publications

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“…Although MSN does not pose an intrinsic therapeutic effect, its excellent biocompatibility provides a great opportunity for drug delivery and imaging in various medical cases ( Tang et al, 2012 ; Luo et al, 2019 ). Other useful properties of MSN are its favorable chemical characteristics, thermal stability, and its controlled drug delivery and release thanks to its silica component ( Kazemzadeh et al, 2022 ). Transferrin-modified MSN has been shown to be well-performed for targeted drug delivery in GBM ( Luo et al, 2019 ; Li et al, 2022a ).…”

Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

“…These properties include their desirable pores’ volume, their favorable loading capacities, their particles’ manageable size and shape, and their convenient way of production. Although, considerable advances have been made in developing and arrangement of MSNs for medical applications, the literature still requires more studies like qualified animal studies before MSNs can be used in the clinical setting ( Kazemzadeh et al, 2022 ).…”

Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

“…However, there are still significant barriers preventing their wide application in clinical trials. These challenges include their relatively unknown long-term adverse effects, the concerns about their safety profile when they are used chronically, the methods for reproducing them, and their useful scale-up methods ( Kazemzadeh et al, 2022 ).…”

Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

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The role of cell membrane-coated nanoparticles as a novel treatment approach in glioblastoma

Allami

Heidari²,

Rezaei³

2023

Front. Mol. Biosci.

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Glioblastoma multiform (GBM) is the most prevalent and deadliest primary brain malignancy in adults, whose median survival rate does not exceed 15 months after diagnosis. The conventional treatment of GBM, including maximal safe surgery followed by chemotherapy and radiotherapy, usually cannot lead to notable improvements in the disease prognosis and the tumor always recurs. Many GBM characteristics make its treatment challenging. The most important ones are the impermeability of the blood-brain barrier (BBB), preventing chemotherapeutic drugs from reaching in adequate amounts to the tumor site, intratumoral heterogeneity, and roles of glioblastoma stem cells (GSCs). To overcome these barriers, the recently-developed drug-carrying approach using nanoparticles (NPs) may play a significant role. NPs are tiny particles, usually less than 100 nm showing various diagnostic and therapeutic medical applications. In this regard, cell membrane (CM)-coated NPs demonstrated several promising effects in GBM in pre-clinical studies. They benefit from fewer adverse effects due to their specific targeting of tumor cells, biocompatibility because of their CM surfaces, prolonged half-life, easy penetrating of the BBB, and escaping from the immune reaction, making them an attractive option for GBM treatment. To date, CM-coated NPs have been applied to enhance the effectiveness of major therapeutic approaches in GBM treatment, including chemotherapy, immunotherapy, gene therapy, and photo-based therapies. Despite the promising results in pre-clinical studies regarding the effectiveness of CM-coated NPs in GBM, significant barriers like high expenses, complex preparation processes, and unknown long-term effects still hinder its mass production for the clinic. In this regard, the current study aims to provide an overview of different characteristics of CM-coated NPs and comprehensively investigate their application as a novel treatment approach in GBM.

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Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

Section: An Overview On Nps In Gbm Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

The role of cell membrane-coated nanoparticles as a novel treatment approach in glioblastoma

Allami

Heidari²,

Rezaei³

2023

Front. Mol. Biosci.

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“…Starting from inorganic precursors, mesoporous silica can have different structures, such as MCM (Mobile Composition of Matter), SBA (Santa Barbara Amorphous), TUD (Technische Universiteit Delft), HMS (Hollow Mesoporous Silica) or MCF (Meso Cellular Form) [ 14 , 15 ]. The MCM family was the first type of mesoporous material synthesized since 1992, which include among other silica types, the hexagonal mesoporous MCM-41 and the cubic mesoporous arranged MCM-48 [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

et al. 2023

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Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.

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“…The discovery of mesoporous materials revolutionized the field of porous materials from the study of zeolite to the later soft and hard template methods [ 5 ]. Mesoporous materials have been widely used in catalysis [ 6 ], biosensing [ 7 ], biomolecular adsorption and separation [ 8 ], drug delivery [ 9 ], regenerative medicine [ 10 ], and other fields due to their performance advantages, such as large surface area, high porosity, orderly and controllable pore size, and good hydrothermal stability.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Cited by 34 publications

References 122 publications

The role of cell membrane-coated nanoparticles as a novel treatment approach in glioblastoma

The role of cell membrane-coated nanoparticles as a novel treatment approach in glioblastoma

Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

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