Structure Properties, Acquisition Protocols, and Biological Activities of Oleuropein Aglycone

Xu, Fangxue; Li, Yujuan; Zheng, Mengmeng; Xi, Xiaozhi; Zhang, Xuelan; Han, Chunchao

doi:10.3389/fchem.2018.00239

Cited by 29 publications

(18 citation statements)

References 63 publications

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“…Besides this, several studies have reported the positive role of OL in improving cognitive anomalies in animal models. This improvement in cognition after OL intake was considered as its role in modulation of the autophagy pathways (Xu et al., 2018). To explore this hypothesis, the first effort was made by Grossi and his co‐workers.…”

Section: Neuroprotective Role Of Oleuropeinmentioning

confidence: 99%

Neuroprotective effects of oleuropein: Recent developments and contemporary research

et al. 2021

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Neurological disorders are increasing at a faster pace due to oxidative stress, protein aggregation, excitotoxicity, and neuroinflammation. It is reported that the Mediterranean diet including olives as a major dietary component prevents and ameliorates neurological anomalies. Oleuropein is the major bioactive component in different parts of the Olive (Olea europaea L.) tree. Several mechanisms have been reported for the neuroprotective role of oleuropein including induction of apoptosis and autophagy, enhancing the antioxidant pool of the cerebral region, decreasing the unnecessary release of proinflammatory cytokines and chemokines by deactivating the microglia cells and astrocytes thus preventing the occurrence of neuroinflammation. Regular intake of oleuropein seems to be correlated with decreased risks of neural disorders including Alzheimer's, Parkinson's, strokes, depression, anxiety, epilepsy, and others. This review majorly discusses the chemistry, biosynthesis, and metabolism of oleuropein along with an updated vision of its neuroprotective role in counteracting the acute and chronic neurodegenerative and neuropsychiatric disorders. Moreover, mechanisms by which oleuropein may prevent neurodegeneration are reviewed. Practical application Neurological disorders are negatively affecting the health and life quality of individuals around the globe. Although various medicinal solutions are available to tackle such ailments, none has proven to fully cure and being deprived of side effects. In this respect, the prevention of such disorders using natural remedies may be an effective strategy to overcome the incidence of the increasing cases. Furthermore, the natural compounds provide a safer alternative to pharmaceutical drugs. Hence, oleuropein from olive tree products is found to be efficacious against neurological disorders. This review provides an updated insight on the positive effects of oleuropein against neurodegenerative and neuropsychiatric disorders. The diet practitioners and nutraceutical companies may benefit from the provided information to design and develop strategies to improve the mental health of suffering individuals.

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Section: Neuroprotective Role Of Oleuropeinmentioning

confidence: 99%

Neuroprotective effects of oleuropein: Recent developments and contemporary research

et al. 2021

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“…Oleuropein aglycon, is liberated in the course of oleuropein de-glycosylation [45]. Research demonstrated that oleuropein aglycon has a great contribution to developing bitterness/astringency [46].…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Olive Tree Leaves—A Source of Valuable Active Compounds

2020

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The agricultural and processing activities of olive crops generate a substantial amount of food by-products, particularly olive leaves, which are mostly underexploited, representing a significant threat to the environment. Olive leaves are endowed with endogenous bioactive compounds. Their beneficial/health-promoting potential, together with environmental protection and circular economy, merit their exploitation to recover and reuse natural components that are potentially safer alternatives to synthetic counterparts. These biomass residues have great potential for extended industrial applications in food/dietary systems but have had limited commercial uses so far. In this regard, many researchers have endeavoured to determine a green/sustainable means to replace the conventional/inefficient methods currently used. This is not an easy task as a sustainable bio-processing approach entails careful designing to maximise the liberation of compounds with minimum use of (i) processing time, (ii) toxic solvent (iii) fossil fuel energy, and (iv) overall cost. Thus, it is necessary to device viable strategies to (i) optimise the extraction of valuable biomolecules from olive leaves and enable their conversion into high added-value products, and (ii) minimise generation of agro-industrial waste streams. This review provides an insight to the principal bioactive components naturally present in olive leaves, and an overview of the existing/proposed methods associated with their analysis, extraction, applications, and stability.

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“…Moreover, a reduction in the number and size of Aβ(1–42) plaques present in the brain cortex of the treated animals was found. In light of the above findings we can conclude that oleuropein aglycone compensates for Aβ aggregation and modulates the neurotoxicity attributed to the last of them and disturbs diverse pathways such as the processing of amyloid precursor proteins, the amyloid-β and tau protein aggregates, autophagy damage and neuroinflammation [39].…”

Section: Low-molecular Weight Compounds Tested For Decreasing Amylmentioning

confidence: 99%

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

et al. 2019

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Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of the identified mechanism involved in disease pathogenesis. The optimal treatment approach leads toward finding a chemical compound able to form a noncovalent complex with the amyloid peptide thus blocking the process of amyloid aggregation. This direction gained an increasing interest lately, many studies demonstrating that mass spectrometry is a valuable method useful for the identification and characterization of such molecules able to interact with amyloid peptides. In the present review we aim to identify in the scientific literature low molecular weight chemical compounds for which there is mass spectrometric evidence of noncovalent complex formation with amyloid peptides and also there are toxicity reduction results which verify the effects of these compounds on amyloid beta toxicity towards cell cultures and transgenic mouse models developing Alzheimer’s Disease.

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Structure Properties, Acquisition Protocols, and Biological Activities of Oleuropein Aglycone

Cited by 29 publications

References 63 publications

Neuroprotective effects of oleuropein: Recent developments and contemporary research

Neuroprotective effects of oleuropein: Recent developments and contemporary research

Olive Tree Leaves—A Source of Valuable Active Compounds

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

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